Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: A near-infrared spectroscopy (NIRS) study

Takeo Tsujii, Sayako Masuda, Eriko Yamamoto, Takayuki Ohira, Takekazu Akiyama, Takao Takahashi, Shigeru Watanabe

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Introduction: Antagonists of histamine H1 receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalPsychopharmacology
Volume207
Issue number1
DOIs
Publication statusPublished - 2009 Nov

Keywords

  • Antihistamines
  • Epinastine
  • Ketotifen
  • Near-infrared spectroscopy (NIRS)
  • Sedation
  • Young children

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: A near-infrared spectroscopy (NIRS) study'. Together they form a unique fingerprint.

  • Cite this