Abstract
Introduction: Antagonists of histamine H1 receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.
| Original language | English |
|---|---|
| Pages (from-to) | 127-132 |
| Number of pages | 6 |
| Journal | Psychopharmacology |
| Volume | 207 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 Nov |
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Keywords
- Antihistamines
- Epinastine
- Ketotifen
- Near-infrared spectroscopy (NIRS)
- Sedation
- Young children
ASJC Scopus subject areas
- Pharmacology
Cite this
Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children : A near-infrared spectroscopy (NIRS) study. / Tsujii, Takeo; Masuda, Sayako; Yamamoto, Eriko; Oohira, Takayuki; Akiyama, Takekazu; Takahashi, Takao; Watanabe, Shigeru.
In: Psychopharmacology, Vol. 207, No. 1, 11.2009, p. 127-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children
T2 - A near-infrared spectroscopy (NIRS) study
AU - Tsujii, Takeo
AU - Masuda, Sayako
AU - Yamamoto, Eriko
AU - Oohira, Takayuki
AU - Akiyama, Takekazu
AU - Takahashi, Takao
AU - Watanabe, Shigeru
PY - 2009/11
Y1 - 2009/11
N2 - Introduction: Antagonists of histamine H1 receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.
AB - Introduction: Antagonists of histamine H1 receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.
KW - Antihistamines
KW - Epinastine
KW - Ketotifen
KW - Near-infrared spectroscopy (NIRS)
KW - Sedation
KW - Young children
UR - http://www.scopus.com/inward/record.url?scp=70350336451&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350336451&partnerID=8YFLogxK
U2 - 10.1007/s00213-009-1640-2
DO - 10.1007/s00213-009-1640-2
M3 - Article
C2 - 19705105
AN - SCOPUS:70350336451
VL - 207
SP - 127
EP - 132
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 1
ER -