Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: A near-infrared spectroscopy (NIRS) study

Takeo Tsujii; Sayako Masuda; Eriko Yamamoto; Takayuki Ohira; Takekazu Akiyama; Takao Takahashi; Shigeru Watanabe

doi:10.1007/s00213-009-1640-2

Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: A near-infrared spectroscopy (NIRS) study

Takeo Tsujii, Sayako Masuda, Eriko Yamamoto, Takayuki Ohira, Takekazu Akiyama, Takao Takahashi, Shigeru Watanabe

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Introduction: Antagonists of histamine H₁ receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.

Original language	English
Pages (from-to)	127-132
Number of pages	6
Journal	Psychopharmacology
Volume	207
Issue number	1
DOIs	https://doi.org/10.1007/s00213-009-1640-2
Publication status	Published - 2009 Nov

Keywords

Antihistamines
Epinastine
Ketotifen
Near-infrared spectroscopy (NIRS)
Sedation
Young children

ASJC Scopus subject areas

Pharmacology

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Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children : A near-infrared spectroscopy (NIRS) study. / Tsujii, Takeo; Masuda, Sayako; Yamamoto, Eriko; Ohira, Takayuki; Akiyama, Takekazu; Takahashi, Takao; Watanabe, Shigeru.

In: Psychopharmacology, Vol. 207, No. 1, 11.2009, p. 127-132.

Research output: Contribution to journal › Article › peer-review

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title = "Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: A near-infrared spectroscopy (NIRS) study",

abstract = "Introduction: Antagonists of histamine H1 receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.",

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author = "Takeo Tsujii and Sayako Masuda and Eriko Yamamoto and Takayuki Ohira and Takekazu Akiyama and Takao Takahashi and Shigeru Watanabe",

note = "Funding Information: Acknowledgments Our thanks go to the 15 young children who participated in the study, as well as to their parents. We also thank Masahito Kobayashi, MD (Department of Neurosurgery, Keio University), Kenjiro Kosaki, MD (Department of Pediatrics, Keio University), and Shozo Kojima, PhD (Department of Psychology, Keio University) for valuable contributions toward the design and execution of this study. Funding for the study was provided by the Japanese Public Health Research Foundation (JPHRF). The study was conducted at Center for Advanced Research on Logic and Sensibility (CARLS) at Keio University and was supported by grants of the Global COE program from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, as well as by Boehringer Ingelheim, which also provided test agents (ketotifen, epinastine, and identical placebos).",

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AU - Yamamoto, Eriko

AU - Ohira, Takayuki

AU - Akiyama, Takekazu

AU - Takahashi, Takao

AU - Watanabe, Shigeru

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N2 - Introduction: Antagonists of histamine H1 receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.

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Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: A near-infrared spectroscopy (NIRS) study

Abstract

Keywords

ASJC Scopus subject areas

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