Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children

A near-infrared spectroscopy (NIRS) study

Takeo Tsujii, Sayako Masuda, Eriko Yamamoto, Takayuki Oohira, Takekazu Akiyama, Takao Takahashi, Shigeru Watanabe

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Introduction: Antagonists of histamine H1 receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalPsychopharmacology
Volume207
Issue number1
DOIs
Publication statusPublished - 2009 Nov

Fingerprint

Histamine H1 Antagonists
Near-Infrared Spectroscopy
Hypnotics and Sedatives
Prefrontal Cortex
Ketotifen
Placebos
Neuroimaging
Hemoglobins
Brain
Pharmaceutical Preparations
epinastine

Keywords

  • Antihistamines
  • Epinastine
  • Ketotifen
  • Near-infrared spectroscopy (NIRS)
  • Sedation
  • Young children

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children : A near-infrared spectroscopy (NIRS) study. / Tsujii, Takeo; Masuda, Sayako; Yamamoto, Eriko; Oohira, Takayuki; Akiyama, Takekazu; Takahashi, Takao; Watanabe, Shigeru.

In: Psychopharmacology, Vol. 207, No. 1, 11.2009, p. 127-132.

Research output: Contribution to journalArticle

@article{fa5fb26996864b8fa2dbdd88cbcf03cd,
title = "Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: A near-infrared spectroscopy (NIRS) study",
abstract = "Introduction: Antagonists of histamine H1 receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.",
keywords = "Antihistamines, Epinastine, Ketotifen, Near-infrared spectroscopy (NIRS), Sedation, Young children",
author = "Takeo Tsujii and Sayako Masuda and Eriko Yamamoto and Takayuki Oohira and Takekazu Akiyama and Takao Takahashi and Shigeru Watanabe",
year = "2009",
month = "11",
doi = "10.1007/s00213-009-1640-2",
language = "English",
volume = "207",
pages = "127--132",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children

T2 - A near-infrared spectroscopy (NIRS) study

AU - Tsujii, Takeo

AU - Masuda, Sayako

AU - Yamamoto, Eriko

AU - Oohira, Takayuki

AU - Akiyama, Takekazu

AU - Takahashi, Takao

AU - Watanabe, Shigeru

PY - 2009/11

Y1 - 2009/11

N2 - Introduction: Antagonists of histamine H1 receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.

AB - Introduction: Antagonists of histamine H1 receptors (antihistamines) are widely used for the treatment of allergic disorders in children. These drugs' sedative effect on brain function, however, has been mostly examined in adults. Objective: The objective of this study was to examine the effects of anitihistamines on prefrontal cortex activity in young children using near-infrared spectroscopy (NIRS), a novel brain-imaging method. Materials and methods: In 15 healthy children (mean age, 7.7 years), we examined changes of oxygenated hemoglobin concentration in the prefrontal cortex while they performed a verbal fluency task 3 h after taking a sedating antihistamine (ketotifen), nonsedating antihistamine (epinastine), or placebo. Results: Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex compared with placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. Conclusions: NIRS revealed that sedating and nonsedating antihistamines exert differential effects on brain hemodynamic response in young children.

KW - Antihistamines

KW - Epinastine

KW - Ketotifen

KW - Near-infrared spectroscopy (NIRS)

KW - Sedation

KW - Young children

UR - http://www.scopus.com/inward/record.url?scp=70350336451&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350336451&partnerID=8YFLogxK

U2 - 10.1007/s00213-009-1640-2

DO - 10.1007/s00213-009-1640-2

M3 - Article

VL - 207

SP - 127

EP - 132

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 1

ER -