Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures

Wentao Hu; Hailong Pei; He Li; Nan Ding; Jinpeng He; Jufang Wang; Yoshiya Furusawa; Ryoichi Hirayama; Yoshitaka Matsumoto; Cuihua Liu; Yinghui Li; Tetsuya Kawata; Guangming Zhou

doi:10.1093/jrr/rrt078

Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures

Wentao Hu, Hailong Pei, He Li, Nan Ding, Jinpeng He, Jufang Wang, Yoshiya Furusawa, Ryoichi Hirayama, Yoshitaka Matsumoto, Cuihua Liu, Yinghui Li, Tetsuya Kawata, Guangming Zhou

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

High atomic number and high-energy (HZE) particles in deep space are of low abundance but substantially contribute to the biological effects of space radiation. Shielding is so far the most effective way to partially protect astronauts from these highly penetrating particles. However, simulated calculations and measurements have predicted that secondary particles resulting from the shielding of cosmic rays produce a significant fraction of the total dose and dose equivalent. In this study, we investigated the biological effects of secondary radiation with two cell types, and with cells exposed in different phases of the cell cycle, by comparing the biological effects of a 200 MeV/u iron beam with a shielded beam in which the energy of the iron ion beam was decreased from 500 MeV/u to 200 MeV/u with PMMA, polyethylene (PE), or aluminum. We found that beam shielding resulted in increased induction of 53BP1 foci and micronuclei in a cell-type-dependent manner compared with the unshielded 200 MeV/u Fe ion beam. These findings provide experimental proof that the biological effects of secondary particles resulting from the interaction between HZE particles and shielding materials should be considered in shielding design.

Original language	English
Pages (from-to)	10-16
Number of pages	7
Journal	Journal of radiation research
Volume	55
Issue number	1
DOIs	https://doi.org/10.1093/jrr/rrt078
Publication status	Published - 2014 Jan 1
Externally published	Yes

Keywords

DNA damage
secondary particles
shielding
space radiation
survival

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging
Health, Toxicology and Mutagenesis

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10.1093/jrr/rrt078

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abstract = "High atomic number and high-energy (HZE) particles in deep space are of low abundance but substantially contribute to the biological effects of space radiation. Shielding is so far the most effective way to partially protect astronauts from these highly penetrating particles. However, simulated calculations and measurements have predicted that secondary particles resulting from the shielding of cosmic rays produce a significant fraction of the total dose and dose equivalent. In this study, we investigated the biological effects of secondary radiation with two cell types, and with cells exposed in different phases of the cell cycle, by comparing the biological effects of a 200 MeV/u iron beam with a shielded beam in which the energy of the iron ion beam was decreased from 500 MeV/u to 200 MeV/u with PMMA, polyethylene (PE), or aluminum. We found that beam shielding resulted in increased induction of 53BP1 foci and micronuclei in a cell-type-dependent manner compared with the unshielded 200 MeV/u Fe ion beam. These findings provide experimental proof that the biological effects of secondary particles resulting from the interaction between HZE particles and shielding materials should be considered in shielding design.",

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T1 - Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures

AU - Hu, Wentao

AU - Pei, Hailong

AU - Li, He

AU - Ding, Nan

AU - He, Jinpeng

AU - Wang, Jufang

AU - Furusawa, Yoshiya

AU - Hirayama, Ryoichi

AU - Matsumoto, Yoshitaka

AU - Liu, Cuihua

AU - Li, Yinghui

AU - Kawata, Tetsuya

AU - Zhou, Guangming

PY - 2014/1/1

Y1 - 2014/1/1

N2 - High atomic number and high-energy (HZE) particles in deep space are of low abundance but substantially contribute to the biological effects of space radiation. Shielding is so far the most effective way to partially protect astronauts from these highly penetrating particles. However, simulated calculations and measurements have predicted that secondary particles resulting from the shielding of cosmic rays produce a significant fraction of the total dose and dose equivalent. In this study, we investigated the biological effects of secondary radiation with two cell types, and with cells exposed in different phases of the cell cycle, by comparing the biological effects of a 200 MeV/u iron beam with a shielded beam in which the energy of the iron ion beam was decreased from 500 MeV/u to 200 MeV/u with PMMA, polyethylene (PE), or aluminum. We found that beam shielding resulted in increased induction of 53BP1 foci and micronuclei in a cell-type-dependent manner compared with the unshielded 200 MeV/u Fe ion beam. These findings provide experimental proof that the biological effects of secondary particles resulting from the interaction between HZE particles and shielding materials should be considered in shielding design.

AB - High atomic number and high-energy (HZE) particles in deep space are of low abundance but substantially contribute to the biological effects of space radiation. Shielding is so far the most effective way to partially protect astronauts from these highly penetrating particles. However, simulated calculations and measurements have predicted that secondary particles resulting from the shielding of cosmic rays produce a significant fraction of the total dose and dose equivalent. In this study, we investigated the biological effects of secondary radiation with two cell types, and with cells exposed in different phases of the cell cycle, by comparing the biological effects of a 200 MeV/u iron beam with a shielded beam in which the energy of the iron ion beam was decreased from 500 MeV/u to 200 MeV/u with PMMA, polyethylene (PE), or aluminum. We found that beam shielding resulted in increased induction of 53BP1 foci and micronuclei in a cell-type-dependent manner compared with the unshielded 200 MeV/u Fe ion beam. These findings provide experimental proof that the biological effects of secondary particles resulting from the interaction between HZE particles and shielding materials should be considered in shielding design.

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KW - shielding

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KW - survival

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Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures

Abstract

Keywords

ASJC Scopus subject areas

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