Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

Mikiko Shimizu, Tsukasa Uno, Kazunobu Sugawara, Tomonori Tateishi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Aims: We determined whether or not the extent of drug interaction of fexofenadine by itraconazole is time-dependent. Methods: In a randomized two-phase crossover study, itraconazole was administered orally for 6 days, and, on days 1, 3 and 6, fexofenadine was administered simultaneously. On another occasion, fexofenadine was administered alone. Results: Itraconazole increased fexofenadine AUC(0, ∞), and the % change for difference was 178% (95% CI 1235, 3379), 205% (95% CI 1539, 3319) and 169% (95% CI 1128, 2987) on days 1, 3 and 6 of the 6 day treatment, respectively. Conclusions: The extent of drug interaction by itraconazole was not time-dependent.

Original languageEnglish
Pages (from-to)372-376
Number of pages5
JournalBritish journal of clinical pharmacology
Volume62
Issue number3
DOIs
Publication statusPublished - 2006 Sep 1

Keywords

  • Drug interaction
  • Fexofenadine
  • Itraconazole
  • Pharmacokinetics
  • Treatment period

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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