Effects of spatial variation of skull and cerebrospinal fluid layers on optical mapping of brain activities

Shuping Wang, Nanae Shibahara, Daishi Kuramashi, Shinpei Okawa, Naoto Kakuta, Eiji Okada, Atsushi Maki, Yukio Yamada

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In order to investigate the effects of anatomical variation in human heads on the optical mapping of brain activity, we perform simulations of optical mapping by solving the photon diffusion equation for layered-models simulating human heads using the finite element method (FEM). Particularly, the effects of the spatial variations in the thicknesses of the skull and cerebrospinal fluid (CSF) layers on mapping images are investigated. Mapping images of single active regions in the gray matter layer are affected by the spatial variations in the skull and CSF layer thicknesses, although the effects are smaller than those of the positions of the active region relative to the data points. The increase in the skull thickness decreases the sensitivity of the images to active regions, while the increase in the CSF layer thickness increases the sensitivity in general. The images of multiple active regions are also influenced by their positions relative to the data points and by their depths from the skin surface.

Original languageEnglish
Pages (from-to)410-420
Number of pages11
JournalOptical Review
Volume17
Issue number4
DOIs
Publication statusPublished - 2010

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cerebrospinal fluid
skull
brain
fluids
sensitivity
finite element method
photons
simulation

Keywords

  • Anatomy of human head
  • CSF layer
  • Optical mapping
  • Photon diffusion equation
  • Skull layer

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Effects of spatial variation of skull and cerebrospinal fluid layers on optical mapping of brain activities. / Wang, Shuping; Shibahara, Nanae; Kuramashi, Daishi; Okawa, Shinpei; Kakuta, Naoto; Okada, Eiji; Maki, Atsushi; Yamada, Yukio.

In: Optical Review, Vol. 17, No. 4, 2010, p. 410-420.

Research output: Contribution to journalArticle

Wang, S, Shibahara, N, Kuramashi, D, Okawa, S, Kakuta, N, Okada, E, Maki, A & Yamada, Y 2010, 'Effects of spatial variation of skull and cerebrospinal fluid layers on optical mapping of brain activities', Optical Review, vol. 17, no. 4, pp. 410-420. https://doi.org/10.1007/s10043-010-0076-6
Wang, Shuping ; Shibahara, Nanae ; Kuramashi, Daishi ; Okawa, Shinpei ; Kakuta, Naoto ; Okada, Eiji ; Maki, Atsushi ; Yamada, Yukio. / Effects of spatial variation of skull and cerebrospinal fluid layers on optical mapping of brain activities. In: Optical Review. 2010 ; Vol. 17, No. 4. pp. 410-420.
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