Effects of sumatriptan on cerebral blood flow under normo- and hypercapnia in rats

Michinari Fukuda, N. Suzuki, S. Maruyama, K. Dobashi, A. Kitamura, F. Sakai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To investigate further the pharmacological mechanism of an anti-migraine drug, sumatriptan, a 5-HT1B/1D receptor agonist, we studied its effect on the cerebral circulation in seven anaesthetized rats, particularly during hypercapnia. After injection of 0.6 or 6.0 μg/kg sumatriptan succinate, no significant change in cerebral blood flow (CBF) was observed either in the striatum or in the parietal cortex. The increase in CBF both in the parietal cortex and the striatum during 5% CO2 inhalation was significantly less when sumatriptan succinate 6.0 μg/kg was injected. Sumatriptan appeared to have a vasoconstrictor effect on the relaxed vessels by CO2 inhalation. This mechanism might be attributable to vasoconstriction through activation of 5-HT1B receptors located in the vascular smooth muscle rather than 5-HT1B receptors in the vascular adventitia.

Original languageEnglish
Pages (from-to)468-473
Number of pages6
JournalCephalalgia
Volume22
Issue number6
DOIs
Publication statusPublished - 2002 Jul 1

Keywords

  • Cerebral blood flow
  • Hypercapnia
  • Migraine attack
  • Serotonin receptor
  • Sumatriptan

ASJC Scopus subject areas

  • Clinical Neurology

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    Fukuda, M., Suzuki, N., Maruyama, S., Dobashi, K., Kitamura, A., & Sakai, F. (2002). Effects of sumatriptan on cerebral blood flow under normo- and hypercapnia in rats. Cephalalgia, 22(6), 468-473. https://doi.org/10.1046/j.1468-2982.2002.00395.x