Effects of surface roughness on anti-thrombogenicity of diamond-like carbon films

T. Hasebe, T. Ishimaru, A. Kamijo, Y. Yoshimoto, T. Yoshimura, S. Yohena, H. Kodama, Atsushi Hotta, K. Takahashi, Tetsuya Suzuki

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The mechanism of biomaterial-associated thrombosis has not been fully elucidated. It is believed that surface roughness of biomaterials is a key factor in influencing thrombogenicity. Diamond-like carbon (DLC) is being considered for widespread clinical use as a surface coating for cardiovascular devices. We previously reported that fluorine doping in DLC films (F-DLC) markedly inhibits platelet adhesion and activation in human blood. To evaluate the effects of surface roughness of coatings on thrombus formation, DLC and F-DLC films were deposited on the three different roughness-controlled polycarbonate (PC) substrates, and platelet adhesion and activation was investigated on each substrate. The surface roughness of DLC-coated PC and F-DLC-coated PC ranged from 4.1 nm to 97 nm. In this range, there were no significant differences in the platelet-covered area among the three grades of differing surface roughness for each coated surface. However, evaluation of the F-DLC films showed significant reductions in platelet adhesion and activation when compared with DLC films for every grade of roughness, suggesting that the inherent chemical characteristics of the surface, such as wettability, interfacial free energy and higher ratios of albumin/fibrinogen adsorption, might be more important in the mechanism of F-DLC non-thrombogenicity.

Original languageEnglish
Pages (from-to)1343-1348
Number of pages6
JournalDiamond and Related Materials
Volume16
Issue number4-7 SPEC. ISS.
DOIs
Publication statusPublished - 2007 Apr

Fingerprint

Diamond like carbon films
polycarbonate
Diamond
Diamonds
surface roughness
Carbon
Surface roughness
diamonds
Platelets
carbon
Polycarbonates
platelets
Adhesion
Chemical activation
Biocompatible Materials
Biomaterials
polycarbonates
adhesion
activation
Coatings

Keywords

  • Diamond-like carbon
  • Fluorine
  • Surface roughness
  • Thrombogenicity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

Cite this

Hasebe, T., Ishimaru, T., Kamijo, A., Yoshimoto, Y., Yoshimura, T., Yohena, S., ... Suzuki, T. (2007). Effects of surface roughness on anti-thrombogenicity of diamond-like carbon films. Diamond and Related Materials, 16(4-7 SPEC. ISS.), 1343-1348. https://doi.org/10.1016/j.diamond.2006.12.009

Effects of surface roughness on anti-thrombogenicity of diamond-like carbon films. / Hasebe, T.; Ishimaru, T.; Kamijo, A.; Yoshimoto, Y.; Yoshimura, T.; Yohena, S.; Kodama, H.; Hotta, Atsushi; Takahashi, K.; Suzuki, Tetsuya.

In: Diamond and Related Materials, Vol. 16, No. 4-7 SPEC. ISS., 04.2007, p. 1343-1348.

Research output: Contribution to journalArticle

Hasebe, T, Ishimaru, T, Kamijo, A, Yoshimoto, Y, Yoshimura, T, Yohena, S, Kodama, H, Hotta, A, Takahashi, K & Suzuki, T 2007, 'Effects of surface roughness on anti-thrombogenicity of diamond-like carbon films', Diamond and Related Materials, vol. 16, no. 4-7 SPEC. ISS., pp. 1343-1348. https://doi.org/10.1016/j.diamond.2006.12.009
Hasebe T, Ishimaru T, Kamijo A, Yoshimoto Y, Yoshimura T, Yohena S et al. Effects of surface roughness on anti-thrombogenicity of diamond-like carbon films. Diamond and Related Materials. 2007 Apr;16(4-7 SPEC. ISS.):1343-1348. https://doi.org/10.1016/j.diamond.2006.12.009
Hasebe, T. ; Ishimaru, T. ; Kamijo, A. ; Yoshimoto, Y. ; Yoshimura, T. ; Yohena, S. ; Kodama, H. ; Hotta, Atsushi ; Takahashi, K. ; Suzuki, Tetsuya. / Effects of surface roughness on anti-thrombogenicity of diamond-like carbon films. In: Diamond and Related Materials. 2007 ; Vol. 16, No. 4-7 SPEC. ISS. pp. 1343-1348.
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