Effects of telmisartan on arterial stiffness assessed by the cardio-ankle vascular index in hypertensive patients

Kenichiro Kinouchi, Atsuhiro Ichihara, Mariyo Sakoda, Asako Kurauchi-Mito, Kanako Murohashi-Bokuda, Hiroshi Itoh

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background/Aims: This study was conducted to determine the effect of telmisartan on the cardio-ankle vascular index (CAVI), a novel blood pressure (BP)-independent marker for arterial stiffness in hypertensive patients. Methods: One hundred consecutive hypertensive patients were randomly assigned either to a group treated with calcium channel blocker (CCB)-based therapy or a group treated with telmisartan-based therapy. Clinical and biological parameters were then measured before and 12 months after the start of this study. Results: CAVI, the logarithm of urinary albumin excretion, and BP were reduced significantly after telmisartan-based therapy. The decreases in 24-hour diastolic BP and daytime systolic BP associated with telmisartan-based therapy were significantly greater than those associated with CCB-based therapy. Both therapies significantly and similarly decreased the clinical BP, 24-hour systolic BP, daytime diastolic BP and serum levels of low-density lipoprotein cholesterol. No significant differences in the metabolic parameters were observed between the two therapies. Conclusion: Telmisartan-based therapy had beneficial effects on arterial stiffness assessed by CAVI, albuminuria, 24-hour BP and metabolism compared with CCB-based therapy. Since these markers are known to influence the future risk of cardiovascular events, telmisartan could be a useful drug for hypertensive patients.

Original languageEnglish
Pages (from-to)304-312
Number of pages9
JournalKidney and Blood Pressure Research
Volume33
Issue number4
DOIs
Publication statusPublished - 2010 Aug 1

Keywords

  • Albuminuria
  • Arterial stiffness
  • Blood pressure
  • Cardio-ankle vascular index
  • Telmisartan

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine

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