Effects of the ethyl and benzyl ethers of indenestrols A and B on cytotoxicity in Chinese hamster V79 cells

Taiko Oda, Noriko Ikeda, Yoshihiro Sato

Research output: Contribution to journalArticle

Abstract

We recently investigated the relationship between the structures of various indenestrols and their cytotoxicity, and reported that indenestrol A (IA), a metabolite of the synthetic nonsteroidal estrogen diethylstilbestrol, and indenestrol B (IB), an analog of IA, disrupt the microtubule architecture of Chinese hamster V79 cells in vitro. We then synthesized 16 optically active indenestrol derivatives by substituting monoethyl, monobenzyl and diethyl ether groups at the 6- and/or 4'-hydroxyl positions, and examined their cytotoxic activities in Chinese hamster V79 cells. The results indicated that the monoethyl ethers had cytotoxic activities similar to monomethyl ethers. However, the (+)- and (-)-monobenzyl ethers were less cytotoxic than the corresponding monomethyl and monoethyl derivatives.

Original languageEnglish
Pages (from-to)119-121
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume23
Issue number1
Publication statusPublished - 2000 Jan

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Ethyl Ethers
Cricetulus
Ethers
Non-Steroidal Estrogens
Estradiol Congeners
Diethylstilbestrol
Microtubules
Hydroxyl Radical
Ether
indenestrol B
indenestrol

Keywords

  • Chinese hamster V79 cell
  • Cytotoxicity
  • Estrogen
  • Indenestrol

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effects of the ethyl and benzyl ethers of indenestrols A and B on cytotoxicity in Chinese hamster V79 cells. / Oda, Taiko; Ikeda, Noriko; Sato, Yoshihiro.

In: Biological and Pharmaceutical Bulletin, Vol. 23, No. 1, 01.2000, p. 119-121.

Research output: Contribution to journalArticle

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