Effects of the oral administration of mosapride citrate on capsule endoscopy completion rate

Yosuke Ida, Naoki Hosoe, Hiroyuki Imaeda, Rieko Bessho, Riko Ichikawa, Makoto Naganuma, Takanori Kanai, Toshifumi Hibi, Haruhiko Ogata

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13 Citations (Scopus)

Abstract

Background/Aims: In capsule endoscopy (CE), the capsule does not always reach the cecum within its battery life, which may reduce its diagnostic yield. We evaluated the effect of mosapride citrate, a 5-hydroxytryptamine-4 agonist that increases gastrointestinal motility, on CE completion. Methods: In a retrospective study, we performed univariate and multivariate analyses for 232 CE procedures performed at our hospital. To identify factors that affect CE completion, the following data were systematically collected: gender, age, gastric transit time (GTT), nonsteroidal anti-inflammatory drug administration, previous abdominal surgery, hospitalization, use of a polyethylene glycol solution, use of mosapride citrate (10 mg), body mass index (BMI), and total recording time. Results: The univariate analysis showed that oral mosapride citrate, GTT, and BMI were associated with improved CE completion. Multivariate analyses showed that oral mosapride citrate (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.01 to 3.91) and GTT (OR, 2.34; 95% CI, 1.13 to 4.87) were significant factors for improving the CE completion. Oral mosapride citrate significantly shortened the GTT and small bowel transit time (SBTT). Conclusions: Oral mosapride citrate reduced the GTT and SBTT during CE and improved the CE completion rate.

Original languageEnglish
Pages (from-to)339-343
Number of pages5
JournalGut and Liver
Volume6
Issue number3
DOIs
Publication statusPublished - 2012 Jul 1

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Keywords

  • Capsule endoscopy
  • Mosapride
  • Prokinetics

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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