Effects of treadmill exercise on bone mass, bone metabolism, and calciotropic hormones in young growing rats

Jun Iwamoto, Chisato Shimamura, Tsuyoshi Takeda, Hitoshi Abe, Shoichi Ichimura, Yoshihiro Sato, Yoshiaki Toyama

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The aim of the present study was to examine the effects of exercise on bone mass, bone metabolism, and calciotropic hormones in young growing rats. Twenty 6-week-old female Wistar rats were randomized into the following four groups with 5 animals each: 7 weeks of exercise, 7 weeks of sedentary control, 11 weeks of exercise, and 11 weeks of sedentary control. The exercise regimen consisted of running on a treadmill at 25 m/min for 1 h each day on 5 days a week. After each period of exercise, the bone mineral content (BMC) of the tibia and fifth lumbar spine was measured by dual-energy X-ray absorptiometry, using a Lunar DPX-L instrument. The femoral length and levels of bone markers and calciotropic hormones were also assessed. Seven and 11 weeks of exercise increased the serum osteocalcin and 1,25-dihydroxyvitamin D3 levels, and decreased the serum parathyroid level. Seven weeks of exercise decreased the urinary deoxypyridinoline level, and 11 weeks of exercise increased the serum alkaline phosphatase level and decreased the serum tartrate-resistant acid phosphatase level. As a result, 7 and 11 weeks of exercise increased the femoral length and tibial BMC, but did not alter the lumbar BMC. The present study demonstrates that treadmill exercise stimulates bone formation and suppresses bone resorption, increases the serum 1,25-dihydroxyvitamin D 3 level, and decreases the serum parathyroid hormone level, resulting in an increase in bone mass with stimulation of longitudinal bone growth, especially at weight-bearing sites, in young growing rats. Further studies with long-term exercise may be needed to obtain a positive effect on the lumbar BMC.

Original languageEnglish
Pages (from-to)26-31
Number of pages6
JournalJournal of Bone and Mineral Metabolism
Volume22
Issue number1
DOIs
Publication statusPublished - 2004

Fingerprint

Hormones
Bone and Bones
Bone Density
Serum
Thigh
Calcitriol
Bone Development
Osteocalcin
Photon Absorptiometry
Weight-Bearing
Bone Resorption
Parathyroid Hormone
Tibia
Osteogenesis
Running
Alkaline Phosphatase
Wistar Rats
Spine

Keywords

  • Bone formation
  • Bone mineral content (BMC)
  • Exercise
  • Parathyroid hormone
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology

Cite this

Effects of treadmill exercise on bone mass, bone metabolism, and calciotropic hormones in young growing rats. / Iwamoto, Jun; Shimamura, Chisato; Takeda, Tsuyoshi; Abe, Hitoshi; Ichimura, Shoichi; Sato, Yoshihiro; Toyama, Yoshiaki.

In: Journal of Bone and Mineral Metabolism, Vol. 22, No. 1, 2004, p. 26-31.

Research output: Contribution to journalArticle

Iwamoto, Jun ; Shimamura, Chisato ; Takeda, Tsuyoshi ; Abe, Hitoshi ; Ichimura, Shoichi ; Sato, Yoshihiro ; Toyama, Yoshiaki. / Effects of treadmill exercise on bone mass, bone metabolism, and calciotropic hormones in young growing rats. In: Journal of Bone and Mineral Metabolism. 2004 ; Vol. 22, No. 1. pp. 26-31.
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