Effects of vasoactive cyclooxygenase products on shunt flow and extravascular lung water in acutely injured lungs

K. Yamaguchi, M. Mori, T. Takasugi, Y. Oyamada, A. Kawai, K. Asano, T. Aoki, H. Fujita, Y. Suzuki

Research output: Contribution to journalArticle

Abstract

Using 50 mongrel dogs with alveolar flooding produced by oleic acid administration, the possible roles of vasoactive cyclooxygenase products on intrapulmonary shunt flow (Q̇(S)/Q̇(T)) and extravascular lung water (ETVI) in acutely injured lungs were assessed. Suppressing cyclooxygenase activity with indomethacin administration diminished the concentrations of thromboxane (TX) B2 and 6-keto-prostaglandin F(1α) (6-keto-PGF(1α)) in arterial blood, resulting in a significant refuction in Q̇(S)/Q̇(T). Furthermore, indomethacin completely suppressed the increase in ETVI. Inhibition of TXA2 generation by OKY-046 (thromboxane A2 synthase blocker) diminished the concentration of TXB2 while increasing that of 6-keto-PGF(1α) in blood. Administration of either OKY-046 or synthetic prostacyclin (PGI2) markedly enhanced Q̇(S)/Q̇(T), in association with an increase in ETVI. In conclusion, the potent vasodilator prostacyclin was considered to enhance shunt flow, leading to the augmentation of edema formation.

Original languageEnglish
Pages (from-to)302-308
Number of pages7
JournalJapanese Journal of Thoracic Diseases
Volume32
Issue number4
Publication statusPublished - 1994 Jan 1

Keywords

  • cyclooxygenase
  • prostacyclin
  • pulmonary edema
  • shunt ratio
  • thromboxane A

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Yamaguchi, K., Mori, M., Takasugi, T., Oyamada, Y., Kawai, A., Asano, K., Aoki, T., Fujita, H., & Suzuki, Y. (1994). Effects of vasoactive cyclooxygenase products on shunt flow and extravascular lung water in acutely injured lungs. Japanese Journal of Thoracic Diseases, 32(4), 302-308.