Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: An exploratory study

Satoko Koganemaru; Fumiyuki Goto; Miki Arai; Keitaro Toshikuni; Makoto Hosoya; Takeshi Wakabayashi; Nobuko Yamamoto; Shujiro Minami; Satoshi Ikeda; Katsunori Ikoma; Tatsuya Mima

doi:10.1016/j.brs.2017.02.005

Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: An exploratory study

Satoko Koganemaru, Fumiyuki Goto, Miki Arai, Keitaro Toshikuni, Makoto Hosoya, Takeshi Wakabayashi, Nobuko Yamamoto, Shujiro Minami, Satoshi Ikeda, Katsunori Ikoma, Tatsuya Mima

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background Vestibular rehabilitation is useful to alleviate chronic dizziness in patients with vestibular dysfunction. It aims to induce neuronal plasticity in the central nervous system (especially in the cerebellum) to promote vestibular compensation. Transcranial cerebellar direct current stimulation (tcDCS) reportedly enhances cerebellar function. Objective/Hypothesis We investigated whether vestibular rehabilitation partially combined with tcDCS is superior to the use of rehabilitation alone for the alleviation of dizziness. Methods Patients with chronic dizziness due to vestibular dysfunction received rehabilitation concurrently with either 20-min tcDCS or sham stimulation for 5 days. Pre- and post-intervention (at 1 month) dizziness handicap inventory (DHI) scores and psychometric and motor parameters were compared. Results Sixteen patients completed the study. DHI scores in the tcDCS group showed significant improvement over those in the sham group (Mann–Whitney U test, p = 0.033). Conclusion Vestibular rehabilitation partially combined with tcDCS appears to be a promising approach.

Original language	English
Pages (from-to)	576-578
Number of pages	3
Journal	Brain Stimulation
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/j.brs.2017.02.005
Publication status	Published - 2017 May
Externally published	Yes

Keywords

Chronic dizziness
Motor learning
Transcranial cerebellar direct current stimulation
Vestibular rehabilitation

ASJC Scopus subject areas

Biophysics
Neuroscience(all)
Clinical Neurology

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10.1016/j.brs.2017.02.005

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Koganemaru, S., Goto, F., Arai, M., Toshikuni, K., Hosoya, M., Wakabayashi, T., Yamamoto, N., Minami, S., Ikeda, S., Ikoma, K., & Mima, T. (2017). Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: An exploratory study. Brain Stimulation, 10(3), 576-578. https://doi.org/10.1016/j.brs.2017.02.005

Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness : An exploratory study. / Koganemaru, Satoko; Goto, Fumiyuki; Arai, Miki; Toshikuni, Keitaro; Hosoya, Makoto ; Wakabayashi, Takeshi; Yamamoto, Nobuko; Minami, Shujiro; Ikeda, Satoshi; Ikoma, Katsunori; Mima, Tatsuya.

In: Brain Stimulation, Vol. 10, No. 3, 05.2017, p. 576-578.

Research output: Contribution to journal › Article › peer-review

Koganemaru, S, Goto, F, Arai, M, Toshikuni, K, Hosoya, M , Wakabayashi, T, Yamamoto, N, Minami, S, Ikeda, S, Ikoma, K & Mima, T 2017, 'Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: An exploratory study', Brain Stimulation, vol. 10, no. 3, pp. 576-578. https://doi.org/10.1016/j.brs.2017.02.005

Koganemaru, Satoko ; Goto, Fumiyuki ; Arai, Miki ; Toshikuni, Keitaro ; Hosoya, Makoto ; Wakabayashi, Takeshi ; Yamamoto, Nobuko ; Minami, Shujiro ; Ikeda, Satoshi ; Ikoma, Katsunori ; Mima, Tatsuya. / Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness : An exploratory study. In: Brain Stimulation. 2017 ; Vol. 10, No. 3. pp. 576-578.

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title = "Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: An exploratory study",

abstract = "Background Vestibular rehabilitation is useful to alleviate chronic dizziness in patients with vestibular dysfunction. It aims to induce neuronal plasticity in the central nervous system (especially in the cerebellum) to promote vestibular compensation. Transcranial cerebellar direct current stimulation (tcDCS) reportedly enhances cerebellar function. Objective/Hypothesis We investigated whether vestibular rehabilitation partially combined with tcDCS is superior to the use of rehabilitation alone for the alleviation of dizziness. Methods Patients with chronic dizziness due to vestibular dysfunction received rehabilitation concurrently with either 20-min tcDCS or sham stimulation for 5 days. Pre- and post-intervention (at 1 month) dizziness handicap inventory (DHI) scores and psychometric and motor parameters were compared. Results Sixteen patients completed the study. DHI scores in the tcDCS group showed significant improvement over those in the sham group (Mann–Whitney U test, p = 0.033). Conclusion Vestibular rehabilitation partially combined with tcDCS appears to be a promising approach.",

keywords = "Chronic dizziness, Motor learning, Transcranial cerebellar direct current stimulation, Vestibular rehabilitation",

author = "Satoko Koganemaru and Fumiyuki Goto and Miki Arai and Keitaro Toshikuni and Makoto Hosoya and Takeshi Wakabayashi and Nobuko Yamamoto and Shujiro Minami and Satoshi Ikeda and Katsunori Ikoma and Tatsuya Mima",

note = "Funding Information: This study was partly supported by a Grant-in-Aid for JSPS Fellows (16J40201), a Grant-in-Aid for Young Scientists (B) (26870321) from the Japan Society for the Promotion of Science, a research grant (2015) from the Nakatomi Foundation (203150700073) (to S.K.), a Grant-in-Aid for Scientific Research (B) 15H03044, a Grant-in-Aid for Scientific Research on Innovative Areas (15H05880, 15H05871) from the Japan Society for the Promotion of Science, STEP2(27280201) and 2736040 from the Japan Agency for Medical Research and Development, AMED (to T.M.). Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

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T1 - Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness

T2 - An exploratory study

AU - Koganemaru, Satoko

AU - Goto, Fumiyuki

AU - Arai, Miki

AU - Toshikuni, Keitaro

AU - Hosoya, Makoto

AU - Wakabayashi, Takeshi

AU - Yamamoto, Nobuko

AU - Minami, Shujiro

AU - Ikeda, Satoshi

AU - Ikoma, Katsunori

AU - Mima, Tatsuya

N1 - Funding Information: This study was partly supported by a Grant-in-Aid for JSPS Fellows (16J40201), a Grant-in-Aid for Young Scientists (B) (26870321) from the Japan Society for the Promotion of Science, a research grant (2015) from the Nakatomi Foundation (203150700073) (to S.K.), a Grant-in-Aid for Scientific Research (B) 15H03044, a Grant-in-Aid for Scientific Research on Innovative Areas (15H05880, 15H05871) from the Japan Society for the Promotion of Science, STEP2(27280201) and 2736040 from the Japan Agency for Medical Research and Development, AMED (to T.M.). Publisher Copyright: © 2017 Elsevier Inc.

PY - 2017/5

Y1 - 2017/5

N2 - Background Vestibular rehabilitation is useful to alleviate chronic dizziness in patients with vestibular dysfunction. It aims to induce neuronal plasticity in the central nervous system (especially in the cerebellum) to promote vestibular compensation. Transcranial cerebellar direct current stimulation (tcDCS) reportedly enhances cerebellar function. Objective/Hypothesis We investigated whether vestibular rehabilitation partially combined with tcDCS is superior to the use of rehabilitation alone for the alleviation of dizziness. Methods Patients with chronic dizziness due to vestibular dysfunction received rehabilitation concurrently with either 20-min tcDCS or sham stimulation for 5 days. Pre- and post-intervention (at 1 month) dizziness handicap inventory (DHI) scores and psychometric and motor parameters were compared. Results Sixteen patients completed the study. DHI scores in the tcDCS group showed significant improvement over those in the sham group (Mann–Whitney U test, p = 0.033). Conclusion Vestibular rehabilitation partially combined with tcDCS appears to be a promising approach.

AB - Background Vestibular rehabilitation is useful to alleviate chronic dizziness in patients with vestibular dysfunction. It aims to induce neuronal plasticity in the central nervous system (especially in the cerebellum) to promote vestibular compensation. Transcranial cerebellar direct current stimulation (tcDCS) reportedly enhances cerebellar function. Objective/Hypothesis We investigated whether vestibular rehabilitation partially combined with tcDCS is superior to the use of rehabilitation alone for the alleviation of dizziness. Methods Patients with chronic dizziness due to vestibular dysfunction received rehabilitation concurrently with either 20-min tcDCS or sham stimulation for 5 days. Pre- and post-intervention (at 1 month) dizziness handicap inventory (DHI) scores and psychometric and motor parameters were compared. Results Sixteen patients completed the study. DHI scores in the tcDCS group showed significant improvement over those in the sham group (Mann–Whitney U test, p = 0.033). Conclusion Vestibular rehabilitation partially combined with tcDCS appears to be a promising approach.

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Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: An exploratory study

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