Effects of weekly one-hour hatha yoga therapy on resilience and stress levels in patients with schizophrenia-spectrum disorders

An eight-week randomized controlled trial

Saeko Ikai, Takefumi Suzuki, Hiroyuki Uchida, Juri Saruta, Keiichi Tsukinoki, Yasuo Fujii, Masaru Mimura

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: To examine the effects of Hatha yoga therapy on resilience, brain-derived neurotrophic factor (BDNF) levels, and salivary alpha amylase (SAA) activity in patients with schizophrenia-spectrum disorders. Design and participants: Single-blinded, randomized controlled study in which outpatients with schizophrenia or related psychotic disorders (according to International Classification of Diseases, 10th Revision) were randomly assigned to a yoga or a control group. Setting: November 2012-April 2013 at Yamanashi Prefectural Kita Hospital, Japan. Interventions: In the yoga group, patients received weekly 1-hour Hatha yoga sessions, in addition to regular treatment, for 8 weeks. Those in the control group underwent regular treatment, which included a daycare rehabilitation program. Outcome measures: Assessments included the 25-item Resilience Scale (RS), Positive and Negative Syndrome Scale (PANSS), plasma and salivary BDNF level, and SAA activity. Results: Fifty patients participated (25 in each group; mean age±standard deviation, 50.9±11.3 years; mean duration of illness, 25.0±10.3 years; mean total PANSS score, 78.2±17.3). No significant differences in changes in any variable from baseline to week 8 were found between the two groups (changes in the yoga group versus the control group: RS score, -1.6±19.9 versus 0.3±17.2; PANSS score, 0.5±12.0 versus 5.0±15.6; plasma BDNF, 41.6±377.0âpg/dl versus 73.4±346.0 pg/dl; SAA, -26.2±72.6 kU/l versus -13.8±68.0 kU/l, respectively). Conclusions: Adjunct yoga therapy showed no positive changes in resilience level or stress markers. Duration and intensity of yoga sessions and the focus on patients with chronic illness may explain the negative observations in light of past positive evidence regarding yoga therapy.

Original languageEnglish
Pages (from-to)823-830
Number of pages8
JournalJournal of Alternative and Complementary Medicine
Volume20
Issue number11
DOIs
Publication statusPublished - 2014 Nov 1

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Yoga
Schizophrenia
Randomized Controlled Trials
Salivary alpha-Amylases
Brain-Derived Neurotrophic Factor
Therapeutics
Control Groups
Outcome Assessment (Health Care)
International Classification of Diseases
Psychotic Disorders
Japan
Chronic Disease
Outpatients
Rehabilitation

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Medicine(all)

Cite this

Effects of weekly one-hour hatha yoga therapy on resilience and stress levels in patients with schizophrenia-spectrum disorders : An eight-week randomized controlled trial. / Ikai, Saeko; Suzuki, Takefumi; Uchida, Hiroyuki; Saruta, Juri; Tsukinoki, Keiichi; Fujii, Yasuo; Mimura, Masaru.

In: Journal of Alternative and Complementary Medicine, Vol. 20, No. 11, 01.11.2014, p. 823-830.

Research output: Contribution to journalArticle

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