Effects of zopiclone, triazolam, and nitrazepam on standing steadiness

Koji Tada, Yuji Sato, Teiichiro Sakai, Naoki Ueda, Kimihiro Kasamo, Takuya Kojima

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We examined the effects of the nonbenzodiazepine hypnotic zopiclone and the benzodiazepine hypnotics triazolam and nitrazepam on standing steadiness. Eight healthy volunteers received placebo, zopiclone (7.5 mg), triazolam (0.25 mg), and nitrazepam (5 mg) in a random-order, double-blind crossover design. Postural sway was assessed before and 1 and 2 h after drug administration using a stabilometer connected to a microcomputer. Triazolam significantly impaired standing steadiness. Zopiclone also impaired standing steadiness but the degree of impairment seemed to be less marked. Nitrazepam 5 mg had no significant effects on postural sway. Triazolam 0.25 mg, zopiclone 7.5 mg, and nitrazepam 5 mg, which are reported to be equipotent to each other as hypnotics, are not equipotent with respect to their effects on postural sway.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalNeuropsychobiology
Volume29
Issue number1
DOIs
Publication statusPublished - 1994 Jan 1

Keywords

  • Nitrazepam
  • Standing steadiness
  • Triazolam
  • Zopiclone

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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  • Cite this

    Tada, K., Sato, Y., Sakai, T., Ueda, N., Kasamo, K., & Kojima, T. (1994). Effects of zopiclone, triazolam, and nitrazepam on standing steadiness. Neuropsychobiology, 29(1), 17-22. https://doi.org/10.1159/000119057