Effects of zopiclone, triazolam, and nitrazepam on standing steadiness

Koji Tada, Yuji Sato, Teiichiro Sakai, Naoki Ueda, Kimihiro Kasamo, Takuya Kojima

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We examined the effects of the nonbenzodiazepine hypnotic zopiclone and the benzodiazepine hypnotics triazolam and nitrazepam on standing steadiness. Eight healthy volunteers received placebo, zopiclone (7.5 mg), triazolam (0.25 mg), and nitrazepam (5 mg) in a random-order, double-blind crossover design. Postural sway was assessed before and 1 and 2 h after drug administration using a stabilometer connected to a microcomputer. Triazolam significantly impaired standing steadiness. Zopiclone also impaired standing steadiness but the degree of impairment seemed to be less marked. Nitrazepam 5 mg had no significant effects on postural sway. Triazolam 0.25 mg, zopiclone 7.5 mg, and nitrazepam 5 mg, which are reported to be equipotent to each other as hypnotics, are not equipotent with respect to their effects on postural sway.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalNeuropsychobiology
Volume29
Issue number1
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

zopiclone
Nitrazepam
Triazolam
Hypnotics and Sedatives
Microcomputers
Benzodiazepines
Cross-Over Studies
Healthy Volunteers
Placebos

Keywords

  • Nitrazepam
  • Standing steadiness
  • Triazolam
  • Zopiclone

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

Cite this

Tada, K., Sato, Y., Sakai, T., Ueda, N., Kasamo, K., & Kojima, T. (1994). Effects of zopiclone, triazolam, and nitrazepam on standing steadiness. Neuropsychobiology, 29(1), 17-22. https://doi.org/10.1159/000119057

Effects of zopiclone, triazolam, and nitrazepam on standing steadiness. / Tada, Koji; Sato, Yuji; Sakai, Teiichiro; Ueda, Naoki; Kasamo, Kimihiro; Kojima, Takuya.

In: Neuropsychobiology, Vol. 29, No. 1, 1994, p. 17-22.

Research output: Contribution to journalArticle

Tada, K, Sato, Y, Sakai, T, Ueda, N, Kasamo, K & Kojima, T 1994, 'Effects of zopiclone, triazolam, and nitrazepam on standing steadiness', Neuropsychobiology, vol. 29, no. 1, pp. 17-22. https://doi.org/10.1159/000119057
Tada, Koji ; Sato, Yuji ; Sakai, Teiichiro ; Ueda, Naoki ; Kasamo, Kimihiro ; Kojima, Takuya. / Effects of zopiclone, triazolam, and nitrazepam on standing steadiness. In: Neuropsychobiology. 1994 ; Vol. 29, No. 1. pp. 17-22.
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