Efficacy and safety of sulbactum/cefoperazone for hepato-biliary infections

Nagao Shinagawa, Shozo Takeda, Sei Ichi Oohira, Yoshikazu Yasuda, Masato Fujisaki, Hidetsugu Saito, Masakazu Ueda, Keiji Mitamura, Takeki Nishio, Masaru Itakura, Masaru Koyama, Masanori Hirano, Rempei Ohyama, Makoto Kako, Yoshihisa Amako, Koichi Okuda, Takehiko Iwasa, Atsushi Sugiyama, Makoto Hirano, Shigeki Takashima & 7 others Nakaaki Ohsawa, Seishi Nakaya, Minoru Yamada, Fujio Zeze, Shinnosuke Tanaka, Kohta Yatsuka, Jun Ishii

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Abstract

We studied efficacy and safety of sulbactam/cefoperazone (SBT/CPT) in the treatment of biliary tract infections in hospitalized patients at 26 hospitals from February 1993 to March 1995. Secondary to dropout, 273 out of 338 patients entered in the study were evaluated, 127 patients with cholecystitis, 132 patients with cholangitis, and 14 patients with liver abscesses. Of these, 93 patients (34.1%) had malignancy as an underlying disease. SDT/CPZ had an efficacy of 79.9% (218 patients; excellent: 52, good: 166), with the efficacy in patients with cholecystitis, cholangitis and liver abscess at 89.0% (113 patients), 77.3% (102 patients) and 21.4% (3 patients), respectively. A significant difference (p<0.05) was observed in the efficacy rates of patients with (59 patients [63.4%]) and without malignancy (159 patients [88.3%]). A total of 84 strains were isolated from bile specimens of 53 patients, and the major isolates were Escherichia coli, Pseudomonas aeruginosa and Enterococcus spp. Two or more bacterial strains were isolated simulateously in 20 patients. Mild or moderate side effects (allergic reaction including rash etc.) were noted in 4 patients (1.18%), and laboratory abnormalities (increased GOT, etc.) were in 16 patients (4.71%) out of the total 338 patients. This study clearly demonstrated that SBT/CPZ retains its excellent clinical efficacy and safety profile, throughout its use over the past decade.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalJapanese Journal of Antibiotics
Volume50
Issue number11
Publication statusPublished - 1997

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Cefoperazone
Safety
Infection
Liver Abscess
Cholecystitis
Cholangitis
Sulbactam

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Shinagawa, N., Takeda, S., Oohira, S. I., Yasuda, Y., Fujisaki, M., Saito, H., ... Ishii, J. (1997). Efficacy and safety of sulbactum/cefoperazone for hepato-biliary infections. Japanese Journal of Antibiotics, 50(11), 13-16.

Efficacy and safety of sulbactum/cefoperazone for hepato-biliary infections. / Shinagawa, Nagao; Takeda, Shozo; Oohira, Sei Ichi; Yasuda, Yoshikazu; Fujisaki, Masato; Saito, Hidetsugu; Ueda, Masakazu; Mitamura, Keiji; Nishio, Takeki; Itakura, Masaru; Koyama, Masaru; Hirano, Masanori; Ohyama, Rempei; Kako, Makoto; Amako, Yoshihisa; Okuda, Koichi; Iwasa, Takehiko; Sugiyama, Atsushi; Hirano, Makoto; Takashima, Shigeki; Ohsawa, Nakaaki; Nakaya, Seishi; Yamada, Minoru; Zeze, Fujio; Tanaka, Shinnosuke; Yatsuka, Kohta; Ishii, Jun.

In: Japanese Journal of Antibiotics, Vol. 50, No. 11, 1997, p. 13-16.

Research output: Contribution to journalArticle

Shinagawa, N, Takeda, S, Oohira, SI, Yasuda, Y, Fujisaki, M, Saito, H, Ueda, M, Mitamura, K, Nishio, T, Itakura, M, Koyama, M, Hirano, M, Ohyama, R, Kako, M, Amako, Y, Okuda, K, Iwasa, T, Sugiyama, A, Hirano, M, Takashima, S, Ohsawa, N, Nakaya, S, Yamada, M, Zeze, F, Tanaka, S, Yatsuka, K & Ishii, J 1997, 'Efficacy and safety of sulbactum/cefoperazone for hepato-biliary infections', Japanese Journal of Antibiotics, vol. 50, no. 11, pp. 13-16.
Shinagawa N, Takeda S, Oohira SI, Yasuda Y, Fujisaki M, Saito H et al. Efficacy and safety of sulbactum/cefoperazone for hepato-biliary infections. Japanese Journal of Antibiotics. 1997;50(11):13-16.
Shinagawa, Nagao ; Takeda, Shozo ; Oohira, Sei Ichi ; Yasuda, Yoshikazu ; Fujisaki, Masato ; Saito, Hidetsugu ; Ueda, Masakazu ; Mitamura, Keiji ; Nishio, Takeki ; Itakura, Masaru ; Koyama, Masaru ; Hirano, Masanori ; Ohyama, Rempei ; Kako, Makoto ; Amako, Yoshihisa ; Okuda, Koichi ; Iwasa, Takehiko ; Sugiyama, Atsushi ; Hirano, Makoto ; Takashima, Shigeki ; Ohsawa, Nakaaki ; Nakaya, Seishi ; Yamada, Minoru ; Zeze, Fujio ; Tanaka, Shinnosuke ; Yatsuka, Kohta ; Ishii, Jun. / Efficacy and safety of sulbactum/cefoperazone for hepato-biliary infections. In: Japanese Journal of Antibiotics. 1997 ; Vol. 50, No. 11. pp. 13-16.
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abstract = "We studied efficacy and safety of sulbactam/cefoperazone (SBT/CPT) in the treatment of biliary tract infections in hospitalized patients at 26 hospitals from February 1993 to March 1995. Secondary to dropout, 273 out of 338 patients entered in the study were evaluated, 127 patients with cholecystitis, 132 patients with cholangitis, and 14 patients with liver abscesses. Of these, 93 patients (34.1{\%}) had malignancy as an underlying disease. SDT/CPZ had an efficacy of 79.9{\%} (218 patients; excellent: 52, good: 166), with the efficacy in patients with cholecystitis, cholangitis and liver abscess at 89.0{\%} (113 patients), 77.3{\%} (102 patients) and 21.4{\%} (3 patients), respectively. A significant difference (p<0.05) was observed in the efficacy rates of patients with (59 patients [63.4{\%}]) and without malignancy (159 patients [88.3{\%}]). A total of 84 strains were isolated from bile specimens of 53 patients, and the major isolates were Escherichia coli, Pseudomonas aeruginosa and Enterococcus spp. Two or more bacterial strains were isolated simulateously in 20 patients. Mild or moderate side effects (allergic reaction including rash etc.) were noted in 4 patients (1.18{\%}), and laboratory abnormalities (increased GOT, etc.) were in 16 patients (4.71{\%}) out of the total 338 patients. This study clearly demonstrated that SBT/CPZ retains its excellent clinical efficacy and safety profile, throughout its use over the past decade.",
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T1 - Efficacy and safety of sulbactum/cefoperazone for hepato-biliary infections

AU - Shinagawa, Nagao

AU - Takeda, Shozo

AU - Oohira, Sei Ichi

AU - Yasuda, Yoshikazu

AU - Fujisaki, Masato

AU - Saito, Hidetsugu

AU - Ueda, Masakazu

AU - Mitamura, Keiji

AU - Nishio, Takeki

AU - Itakura, Masaru

AU - Koyama, Masaru

AU - Hirano, Masanori

AU - Ohyama, Rempei

AU - Kako, Makoto

AU - Amako, Yoshihisa

AU - Okuda, Koichi

AU - Iwasa, Takehiko

AU - Sugiyama, Atsushi

AU - Hirano, Makoto

AU - Takashima, Shigeki

AU - Ohsawa, Nakaaki

AU - Nakaya, Seishi

AU - Yamada, Minoru

AU - Zeze, Fujio

AU - Tanaka, Shinnosuke

AU - Yatsuka, Kohta

AU - Ishii, Jun

PY - 1997

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