Abstract
Background: To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with esophageal cancer aged 75 and older. Patients and Methods: Twenty-two elderly patients were treated with concurrent chemoradiation. Seventeen received a combination of cisplatin/carboplatin and 5-fluorouracil, 5 received daily 5-fluorouracil. Total doses of radiotherapy ranged from 50 to 65 Gy. Results: Nineteen out of 22 patients completed the planned chemoradiation. Five in 8 patients (63%) with T1-2 lesion and 1 in 14 patients (7%) with T3-4 lesion achieved complete response (p=0.011). Only 2 patients experienced grade 3 toxicities. Grade 2 or worse hematological toxicities were less frequently observed in patients who received local-field radiotherapy (p=0.006). There was no isolated lymph node recurrence. The median survival time was 9 months. Conclusion: This study showed the potential for chemoradiation in elderly patients. A planning target volume of radiotherapy should include only clinically involved lesions in this setting.
| Original language | English |
|---|---|
| Pages (from-to) | 2483-2486 |
| Number of pages | 4 |
| Journal | Anticancer Research |
| Volume | 24 |
| Issue number | 4 |
| Publication status | Published - 2004 Jul |
| Externally published | Yes |
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Keywords
- Chemotherapy
- Elderly
- Esophageal cancer
- Radiotherapy
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancer. / Uno, Takashi; Isobe, Koichi; Kawakami, Hiroyuki; Ueno, Naoyuki; Kobayashi, Hiroki; Shimada, Hideaki; Mastubara, Hisahiro; Okazumi, Shinichi; Nabeya, Yoshihiro; Shiratori, Touru; Ochiai, Takenori; Kawata, Tetsuya; Ito, Hisao.
In: Anticancer Research, Vol. 24, No. 4, 07.2004, p. 2483-2486.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancer
AU - Uno, Takashi
AU - Isobe, Koichi
AU - Kawakami, Hiroyuki
AU - Ueno, Naoyuki
AU - Kobayashi, Hiroki
AU - Shimada, Hideaki
AU - Mastubara, Hisahiro
AU - Okazumi, Shinichi
AU - Nabeya, Yoshihiro
AU - Shiratori, Touru
AU - Ochiai, Takenori
AU - Kawata, Tetsuya
AU - Ito, Hisao
PY - 2004/7
Y1 - 2004/7
N2 - Background: To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with esophageal cancer aged 75 and older. Patients and Methods: Twenty-two elderly patients were treated with concurrent chemoradiation. Seventeen received a combination of cisplatin/carboplatin and 5-fluorouracil, 5 received daily 5-fluorouracil. Total doses of radiotherapy ranged from 50 to 65 Gy. Results: Nineteen out of 22 patients completed the planned chemoradiation. Five in 8 patients (63%) with T1-2 lesion and 1 in 14 patients (7%) with T3-4 lesion achieved complete response (p=0.011). Only 2 patients experienced grade 3 toxicities. Grade 2 or worse hematological toxicities were less frequently observed in patients who received local-field radiotherapy (p=0.006). There was no isolated lymph node recurrence. The median survival time was 9 months. Conclusion: This study showed the potential for chemoradiation in elderly patients. A planning target volume of radiotherapy should include only clinically involved lesions in this setting.
AB - Background: To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with esophageal cancer aged 75 and older. Patients and Methods: Twenty-two elderly patients were treated with concurrent chemoradiation. Seventeen received a combination of cisplatin/carboplatin and 5-fluorouracil, 5 received daily 5-fluorouracil. Total doses of radiotherapy ranged from 50 to 65 Gy. Results: Nineteen out of 22 patients completed the planned chemoradiation. Five in 8 patients (63%) with T1-2 lesion and 1 in 14 patients (7%) with T3-4 lesion achieved complete response (p=0.011). Only 2 patients experienced grade 3 toxicities. Grade 2 or worse hematological toxicities were less frequently observed in patients who received local-field radiotherapy (p=0.006). There was no isolated lymph node recurrence. The median survival time was 9 months. Conclusion: This study showed the potential for chemoradiation in elderly patients. A planning target volume of radiotherapy should include only clinically involved lesions in this setting.
KW - Chemotherapy
KW - Elderly
KW - Esophageal cancer
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=4444298230&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4444298230&partnerID=8YFLogxK
M3 - Article
C2 - 15330202
AN - SCOPUS:4444298230
VL - 24
SP - 2483
EP - 2486
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 4
ER -