Abstract
Background: To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with esophageal cancer aged 75 and older. Patients and Methods: Twenty-two elderly patients were treated with concurrent chemoradiation. Seventeen received a combination of cisplatin/carboplatin and 5-fluorouracil, 5 received daily 5-fluorouracil. Total doses of radiotherapy ranged from 50 to 65 Gy. Results: Nineteen out of 22 patients completed the planned chemoradiation. Five in 8 patients (63%) with T1-2 lesion and 1 in 14 patients (7%) with T3-4 lesion achieved complete response (p=0.011). Only 2 patients experienced grade 3 toxicities. Grade 2 or worse hematological toxicities were less frequently observed in patients who received local-field radiotherapy (p=0.006). There was no isolated lymph node recurrence. The median survival time was 9 months. Conclusion: This study showed the potential for chemoradiation in elderly patients. A planning target volume of radiotherapy should include only clinically involved lesions in this setting.
| Original language | English |
|---|---|
| Pages (from-to) | 2483-2486 |
| Number of pages | 4 |
| Journal | Anticancer research |
| Volume | 24 |
| Issue number | 4 |
| Publication status | Published - 2004 Jul |
Keywords
- Chemotherapy
- Elderly
- Esophageal cancer
- Radiotherapy
ASJC Scopus subject areas
- Oncology
- Cancer Research