Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancer

Takashi Uno; Koichi Isobe; Hiroyuki Kawakami; Naoyuki Ueno; Hiroki Kobayashi; Hideaki Shimada; Hisahiro Mastubara; Shinichi Okazumi; Yoshihiro Nabeya; Touru Shiratori; Takenori Ochiai; Tetsuya Kawata; Hisao Ito

Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancer

Takashi Uno, Koichi Isobe, Hiroyuki Kawakami, Naoyuki Ueno, Hiroki Kobayashi, Hideaki Shimada, Hisahiro Mastubara, Shinichi Okazumi, Yoshihiro Nabeya, Touru Shiratori, Takenori Ochiai, Tetsuya Kawata, Hisao Ito

Department of Radiology

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Background: To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with esophageal cancer aged 75 and older. Patients and Methods: Twenty-two elderly patients were treated with concurrent chemoradiation. Seventeen received a combination of cisplatin/carboplatin and 5-fluorouracil, 5 received daily 5-fluorouracil. Total doses of radiotherapy ranged from 50 to 65 Gy. Results: Nineteen out of 22 patients completed the planned chemoradiation. Five in 8 patients (63%) with T1-2 lesion and 1 in 14 patients (7%) with T3-4 lesion achieved complete response (p=0.011). Only 2 patients experienced grade 3 toxicities. Grade 2 or worse hematological toxicities were less frequently observed in patients who received local-field radiotherapy (p=0.006). There was no isolated lymph node recurrence. The median survival time was 9 months. Conclusion: This study showed the potential for chemoradiation in elderly patients. A planning target volume of radiotherapy should include only clinically involved lesions in this setting.

Original language	English
Pages (from-to)	2483-2486
Number of pages	4
Journal	Anticancer research
Volume	24
Issue number	4
Publication status	Published - 2004 Jul

Keywords

Chemotherapy
Elderly
Esophageal cancer
Radiotherapy

ASJC Scopus subject areas

Oncology
Cancer Research

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Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancer. / Uno, Takashi; Isobe, Koichi; Kawakami, Hiroyuki; Ueno, Naoyuki; Kobayashi, Hiroki; Shimada, Hideaki; Mastubara, Hisahiro; Okazumi, Shinichi; Nabeya, Yoshihiro; Shiratori, Touru; Ochiai, Takenori; Kawata, Tetsuya; Ito, Hisao.

In: Anticancer research, Vol. 24, No. 4, 07.2004, p. 2483-2486.

Research output: Contribution to journal › Article › peer-review

Uno, Takashi ; Isobe, Koichi ; Kawakami, Hiroyuki ; Ueno, Naoyuki ; Kobayashi, Hiroki ; Shimada, Hideaki ; Mastubara, Hisahiro ; Okazumi, Shinichi ; Nabeya, Yoshihiro ; Shiratori, Touru ; Ochiai, Takenori ; Kawata, Tetsuya ; Ito, Hisao. / Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancer. In: Anticancer research. 2004 ; Vol. 24, No. 4. pp. 2483-2486.

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abstract = "Background: To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with esophageal cancer aged 75 and older. Patients and Methods: Twenty-two elderly patients were treated with concurrent chemoradiation. Seventeen received a combination of cisplatin/carboplatin and 5-fluorouracil, 5 received daily 5-fluorouracil. Total doses of radiotherapy ranged from 50 to 65 Gy. Results: Nineteen out of 22 patients completed the planned chemoradiation. Five in 8 patients (63%) with T1-2 lesion and 1 in 14 patients (7%) with T3-4 lesion achieved complete response (p=0.011). Only 2 patients experienced grade 3 toxicities. Grade 2 or worse hematological toxicities were less frequently observed in patients who received local-field radiotherapy (p=0.006). There was no isolated lymph node recurrence. The median survival time was 9 months. Conclusion: This study showed the potential for chemoradiation in elderly patients. A planning target volume of radiotherapy should include only clinically involved lesions in this setting.",

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AU - Kobayashi, Hiroki

AU - Shimada, Hideaki

AU - Mastubara, Hisahiro

AU - Okazumi, Shinichi

AU - Nabeya, Yoshihiro

AU - Shiratori, Touru

AU - Ochiai, Takenori

AU - Kawata, Tetsuya

AU - Ito, Hisao

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AB - Background: To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with esophageal cancer aged 75 and older. Patients and Methods: Twenty-two elderly patients were treated with concurrent chemoradiation. Seventeen received a combination of cisplatin/carboplatin and 5-fluorouracil, 5 received daily 5-fluorouracil. Total doses of radiotherapy ranged from 50 to 65 Gy. Results: Nineteen out of 22 patients completed the planned chemoradiation. Five in 8 patients (63%) with T1-2 lesion and 1 in 14 patients (7%) with T3-4 lesion achieved complete response (p=0.011). Only 2 patients experienced grade 3 toxicities. Grade 2 or worse hematological toxicities were less frequently observed in patients who received local-field radiotherapy (p=0.006). There was no isolated lymph node recurrence. The median survival time was 9 months. Conclusion: This study showed the potential for chemoradiation in elderly patients. A planning target volume of radiotherapy should include only clinically involved lesions in this setting.

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