Efficacy of 18-FDG PET-CT dual-phase scanning for detection of lymph node metastasis in gynecological cancer

Yuya Nogami, Kouji Banno, Haruko Irie, Miho Iida, Yohei Masugi, Koji Murakami, Daisuke Aoki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: This study investigated whether dual-phase scanning (DPS) with 18-fludeoxyglucose positron emission tomography -computed tomography (FDG PET-CT) improves diagnosis of lymph node metastasis (LNM) in gynecologic malignancies, compared to mono-phase scanning (MPS). Patients and Methods: The study included 139 patients who underwent PET-CT followed by systemic lymph node dissection. PET-CT scans were obtained twice. The maximum standardized uptake value (SUVmax) was measured and the retention index (RI) was calculated as the % change from the early to the delayed scan. The optimal threshold of RI was determined using a receiver operating characteristic (ROC) curve. Diagnostic efficacies were calculated for MPS and DPS using pathological results. Results: In total, 1,879 regions were dissected. The optimal RI was 9%. The sensitivity, specificity and accuracy were 35.8%, 99.0% and 96.8% for MPS and 26.9%, 99.6% and 97.0% for DPS, respectively. Specificity was significantly improved by DPS and accuracy was also improved, but not significantly. Conclusion: DPS had an unsatisfactory impact on the diagnostic efficacy for LNM.

Original languageEnglish
Pages (from-to)2247-2253
Number of pages7
JournalAnticancer Research
Volume35
Issue number4
Publication statusPublished - 2015 Apr 1

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Lymph Nodes
Neoplasm Metastasis
Neoplasms
Lymph Node Excision
ROC Curve
Sensitivity and Specificity
Positron Emission Tomography Computed Tomography

Keywords

  • Clinical oncology
  • Diagnostic imaging
  • Gynecology
  • Lymphatic metastasis
  • Positron emission tomography

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Efficacy of 18-FDG PET-CT dual-phase scanning for detection of lymph node metastasis in gynecological cancer. / Nogami, Yuya; Banno, Kouji; Irie, Haruko; Iida, Miho; Masugi, Yohei; Murakami, Koji; Aoki, Daisuke.

In: Anticancer Research, Vol. 35, No. 4, 01.04.2015, p. 2247-2253.

Research output: Contribution to journalArticle

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abstract = "Aim: This study investigated whether dual-phase scanning (DPS) with 18-fludeoxyglucose positron emission tomography -computed tomography (FDG PET-CT) improves diagnosis of lymph node metastasis (LNM) in gynecologic malignancies, compared to mono-phase scanning (MPS). Patients and Methods: The study included 139 patients who underwent PET-CT followed by systemic lymph node dissection. PET-CT scans were obtained twice. The maximum standardized uptake value (SUVmax) was measured and the retention index (RI) was calculated as the {\%} change from the early to the delayed scan. The optimal threshold of RI was determined using a receiver operating characteristic (ROC) curve. Diagnostic efficacies were calculated for MPS and DPS using pathological results. Results: In total, 1,879 regions were dissected. The optimal RI was 9{\%}. The sensitivity, specificity and accuracy were 35.8{\%}, 99.0{\%} and 96.8{\%} for MPS and 26.9{\%}, 99.6{\%} and 97.0{\%} for DPS, respectively. Specificity was significantly improved by DPS and accuracy was also improved, but not significantly. Conclusion: DPS had an unsatisfactory impact on the diagnostic efficacy for LNM.",
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AU - Iida, Miho

AU - Masugi, Yohei

AU - Murakami, Koji

AU - Aoki, Daisuke

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