Efficacy of a high FFP:PRBC transfusion ratio on the survival of severely injured patients: A retrospective study in a single tertiary emergency center in Japan

Daisuke Kudo, Junichi Sasaki, Satoshi Akaishi, Satoshi Yamanouchi, Tomoaki Koakutsu, Tomoyuki Endo, Takeaki Sato, Ryosuke Nomura, Hironao Yuzawa, Michio Kobayashi, Yotaro Shinozawa, Shigeki Kushimoto

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7 Citations (Scopus)

Abstract

Purpose: Recent studies have shown increased survival benefits when a high fresh frozen plasma (FFP) to packed red blood cell (PRBC) ratio is used during trauma resuscitation. However, some reports have raised questions about the effect of higher FFP:PRBC transfusion ratios. The aim of this study was to examine the efficacy of high FFP:PRBC ratios in injured patients with regard to survival and morbidity in a single tertiary emergency center in Japan. Methods: This study examined severe trauma patients who received 10 or more PRBC units during the first 24 h of admission. We examined the relationship between the FFP:PRBC ratios during the first 6 h and the patient outcome. Results: The severity was similar among all groups. The mortality rate was 44.4 % in the high (>1:1.5), 16.7 % in the middle (1:1.5-1:2) and 33.3 % in the low (<1:2) F:P ratio groups. Only one patient in the high group developed sepsis, and none of the patients developed ARDS. Conclusions: The current results indicate that the FFP:PRBC ratios during the first 6 h after admission might not affect the mortality or morbidity. However, differences between trauma care systems in Japan and other countries, along with other study limitations, necessitate that a subsequent prospective multicenter study be undertaken before any definitive conclusions can be made.

Original languageEnglish
Pages (from-to)653-661
Number of pages9
JournalSurgery today
Volume44
Issue number4
DOIs
Publication statusPublished - 2014 Apr

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Keywords

  • Fresh frozen plasma
  • Hemostatic resuscitation
  • Massive transfusion
  • Postinjury
  • Transfusion ratio

ASJC Scopus subject areas

  • Surgery

Cite this

Kudo, D., Sasaki, J., Akaishi, S., Yamanouchi, S., Koakutsu, T., Endo, T., Sato, T., Nomura, R., Yuzawa, H., Kobayashi, M., Shinozawa, Y., & Kushimoto, S. (2014). Efficacy of a high FFP:PRBC transfusion ratio on the survival of severely injured patients: A retrospective study in a single tertiary emergency center in Japan. Surgery today, 44(4), 653-661. https://doi.org/10.1007/s00595-013-0518-4