Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel

Masahiro Wada, Hiromitsu Jinno, Masakazu Ueda, Tadashi Ikeda, Masaki Kitajima, Tomohiro Konno, Junji Watanabe, Kazuhiko Ishihara

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: Paclitaxel (PTX) is administered as a solution in polyoxyethylated castor oil (CO) due to its low water solubility, but solvent-induced side-effects may be severe. Materials and Methods: PMB30W is a co-polymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and butyl methacrylate (BMA). Cytotoxicities of PTX in PMB30W (PTX-PMB30W) were examined in cell culture and in vivo. Results: PTX-PMB30W and PTX in dimethyl sulfoxide showed similar toxicity in breast cancer cell lines MCF-7, SK-BR-3 and MX-1. Antitumor efficacies of PTX-PMB30W and PTX in CO (PTX-CO) were similar following weekly intraperitoneal administration of 50 mg/kg PTX in nude mice transplanted with MX-1 cells. At 200 mg/kg PTX, all animals died within 1 minute of PTX-CO administration. However, all animals receiving PTX-PBM30W survived. Ulceration occurred following subcutaneous injection of PTX-CO, but injection of PTX-PMB30W did not cause skin changes. Conclusion: Our data suggest that PMB30W can act as an effective PTX nanotransporter.

Original languageEnglish
Pages (from-to)1431-1435
Number of pages5
JournalAnticancer Research
Volume27
Issue number3 B
Publication statusPublished - 2007 May

Fingerprint

Phosphorylcholine
Paclitaxel
Polymers
Castor Oil
butyl methacrylate
Subcutaneous Injections
Dimethyl Sulfoxide
Nude Mice
Solubility
poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate)
Cell Culture Techniques

Keywords

  • 2-methacryloyloxyethyl phosphorylcholine (MPC)
  • Co-polymer
  • Paclitaxel (PTX)
  • Tumour

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Wada, M., Jinno, H., Ueda, M., Ikeda, T., Kitajima, M., Konno, T., ... Ishihara, K. (2007). Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel. Anticancer Research, 27(3 B), 1431-1435.

Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel. / Wada, Masahiro; Jinno, Hiromitsu; Ueda, Masakazu; Ikeda, Tadashi; Kitajima, Masaki; Konno, Tomohiro; Watanabe, Junji; Ishihara, Kazuhiko.

In: Anticancer Research, Vol. 27, No. 3 B, 05.2007, p. 1431-1435.

Research output: Contribution to journalArticle

Wada, M, Jinno, H, Ueda, M, Ikeda, T, Kitajima, M, Konno, T, Watanabe, J & Ishihara, K 2007, 'Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel', Anticancer Research, vol. 27, no. 3 B, pp. 1431-1435.
Wada M, Jinno H, Ueda M, Ikeda T, Kitajima M, Konno T et al. Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel. Anticancer Research. 2007 May;27(3 B):1431-1435.
Wada, Masahiro ; Jinno, Hiromitsu ; Ueda, Masakazu ; Ikeda, Tadashi ; Kitajima, Masaki ; Konno, Tomohiro ; Watanabe, Junji ; Ishihara, Kazuhiko. / Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel. In: Anticancer Research. 2007 ; Vol. 27, No. 3 B. pp. 1431-1435.
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