Efficacy of mesalamine enema in the treatment of steroid-resistant or dependent distal ulcerative colitis

Makoto Naganuma, Yasushi Iwao, Haruhiko Ogata, S. Funakoshi, H. Takagi, M. Nakano, O. Hitotsumatsu, T. Ezaki, T. Hisamatsu, Nagamu Inoue, T. Hibi, H. Ishii

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Abstract

The efficacy and safety of mesalamine enema were examined in 20 patients with steroid-resistant or dependent, distal ulcarative colitis. Rectal bleeding disappeared in 3 (18%), 8 (50%) of 16 patients within 2 weeks and 4 weeks after the start of mesalamine enema treatment, respectively. Mean clinical activity index (CAI) score after the treatment was significantly reduced (8.1→3.6, p<0.001). Furthermore, Mean doses of oral corticosteroid after the treatment (7.3mg) were also significantly lower than those before the treatment (12.8mg) (p<0.01). Four patients dropped out. Three patients could not retain the enemas because of abdominal discomfort and one patient had fever and rash. There were no significant differences in age, gender, disease duration, disease type, and mean doses of oral corticosteroid before the treatment between the response group (n=8) and the non-response group (n=8). However, clinical and endoscopic activities before mesalamine enema treatment in the non-response group (CAI 9.8, Matts score 8.0) were higher than those in the response group (CAI 6.4, Matts score 5.5). These results suggest that mesalamine enema is useful for mildly to moderately active distal ulcerative colitis by improving clinical symptoms and reducing corticosteroid.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalJapanese Journal of Gastroenterology
Volume98
Issue number2
Publication statusPublished - 2001

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Mesalamine
Enema
Ulcerative Colitis
Steroids
Adrenal Cortex Hormones
Therapeutics
Colitis
Exanthema
Fever
Hemorrhage
Safety

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Efficacy of mesalamine enema in the treatment of steroid-resistant or dependent distal ulcerative colitis. / Naganuma, Makoto; Iwao, Yasushi; Ogata, Haruhiko; Funakoshi, S.; Takagi, H.; Nakano, M.; Hitotsumatsu, O.; Ezaki, T.; Hisamatsu, T.; Inoue, Nagamu; Hibi, T.; Ishii, H.

In: Japanese Journal of Gastroenterology, Vol. 98, No. 2, 2001, p. 151-156.

Research output: Contribution to journalArticle

Naganuma, M, Iwao, Y, Ogata, H, Funakoshi, S, Takagi, H, Nakano, M, Hitotsumatsu, O, Ezaki, T, Hisamatsu, T, Inoue, N, Hibi, T & Ishii, H 2001, 'Efficacy of mesalamine enema in the treatment of steroid-resistant or dependent distal ulcerative colitis', Japanese Journal of Gastroenterology, vol. 98, no. 2, pp. 151-156.
Naganuma, Makoto ; Iwao, Yasushi ; Ogata, Haruhiko ; Funakoshi, S. ; Takagi, H. ; Nakano, M. ; Hitotsumatsu, O. ; Ezaki, T. ; Hisamatsu, T. ; Inoue, Nagamu ; Hibi, T. ; Ishii, H. / Efficacy of mesalamine enema in the treatment of steroid-resistant or dependent distal ulcerative colitis. In: Japanese Journal of Gastroenterology. 2001 ; Vol. 98, No. 2. pp. 151-156.
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