Efficacy of predetermined therapeutic measures against bleb-related infection in the Collaborative Bleb-related Infection Incidence and Treatment Study

the Collaborative Bleb-Related Infection Incidence and Treatment Study Group

Research output: Contribution to journalArticle

Abstract

Purpose: To report the efficacy of the predetermined treatment protocol of the Collaborative Bleb-related Infection Incidence and Treatment Study (CBIITS) for bleb-related infection (BRI) patients. Methods: A prospective, observational cohort study was conducted at 34 clinical centres in Japan. Nineteen eyes from 19 patients that developed BRI were treated using the CBIITS protocol at 34 clinical centres. The visual acuity (VA) and intraocular pressure (IOP) were monitored for 6 and 12 months after treatment with the predetermined protocol. Results: The logMAR was 0.623 ± 0.748 (mean ± standard deviation) before the infection developed. It was 1.054 ± 1.156 and 0.950 ± 1.168 at 6 months and 12 months post-infection, respectively. However, in subgroup analyses, there was no significant decrease in post-infection logMAR in stages I and II. In contrast, decimal VA was decreased ≥2 lines in all four cases in stage III. The IOP did not change after infection. It was 10.2 ± 5.0 mmHg (range, 3–22 mmHg) before the infection developed, and 12.9 ± 5.2 mmHg (5–24 mmHg) and 10.7 ± 4.7 mmHg (3–18 mmHg) at 6 months and 12 months after infection, respectively. Conclusion: Because of the small number of BRI patients, the superiority of the treatment was not definitively determined. However, VA was almost maintained in stages I and II, and the IOP did not change after infection. Although further study is necessary, the treatment protocol shown in the study might be a valuable treatment regime.

Original languageEnglish
Pages (from-to)e229-e236
JournalActa Ophthalmologica
Volume96
Issue number2
DOIs
Publication statusPublished - 2018 Mar 1

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Cohort Studies
Infection
Therapeutics
Clinical Protocols
Intraocular Pressure
Visual Acuity
Observational Studies
Japan

Keywords

  • bleb-related infection
  • blebitis
  • predetermined treatment protocol
  • trabeculectomy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Efficacy of predetermined therapeutic measures against bleb-related infection in the Collaborative Bleb-related Infection Incidence and Treatment Study. / the Collaborative Bleb-Related Infection Incidence and Treatment Study Group.

In: Acta Ophthalmologica, Vol. 96, No. 2, 01.03.2018, p. e229-e236.

Research output: Contribution to journalArticle

the Collaborative Bleb-Related Infection Incidence and Treatment Study Group. / Efficacy of predetermined therapeutic measures against bleb-related infection in the Collaborative Bleb-related Infection Incidence and Treatment Study. In: Acta Ophthalmologica. 2018 ; Vol. 96, No. 2. pp. e229-e236.
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abstract = "Purpose: To report the efficacy of the predetermined treatment protocol of the Collaborative Bleb-related Infection Incidence and Treatment Study (CBIITS) for bleb-related infection (BRI) patients. Methods: A prospective, observational cohort study was conducted at 34 clinical centres in Japan. Nineteen eyes from 19 patients that developed BRI were treated using the CBIITS protocol at 34 clinical centres. The visual acuity (VA) and intraocular pressure (IOP) were monitored for 6 and 12 months after treatment with the predetermined protocol. Results: The logMAR was 0.623 ± 0.748 (mean ± standard deviation) before the infection developed. It was 1.054 ± 1.156 and 0.950 ± 1.168 at 6 months and 12 months post-infection, respectively. However, in subgroup analyses, there was no significant decrease in post-infection logMAR in stages I and II. In contrast, decimal VA was decreased ≥2 lines in all four cases in stage III. The IOP did not change after infection. It was 10.2 ± 5.0 mmHg (range, 3–22 mmHg) before the infection developed, and 12.9 ± 5.2 mmHg (5–24 mmHg) and 10.7 ± 4.7 mmHg (3–18 mmHg) at 6 months and 12 months after infection, respectively. Conclusion: Because of the small number of BRI patients, the superiority of the treatment was not definitively determined. However, VA was almost maintained in stages I and II, and the IOP did not change after infection. Although further study is necessary, the treatment protocol shown in the study might be a valuable treatment regime.",
keywords = "bleb-related infection, blebitis, predetermined treatment protocol, trabeculectomy",
author = "{the Collaborative Bleb-Related Infection Incidence and Treatment Study Group} and Nobuyuki Shoji and Yoshikuni Arakaki and Kenji Nakamoto and Tetsuya Yamamoto and Yasuaki Kuwayama and Yumiko Aoyama and Kazuhide Kawase and Takahiro Ban and Akira Sawada and Kiyofumi Mochizuki and Ryusuke Futa and Noriko Yasuda and Masayuki Nakajima and Tetsuya Sugiyama and Shota Kojima and Norihiko Hirotsuji and Kiyoshi Kano and Atsushi Ohura and Eriko Kawai and Atsuko Nakata and Rika Kuwamura and Kensuke Okuno and Kenji Yawata and Shun Matsumoto and Haruki Abe and Takeo Fukuchi and Motohiro Shirakashi and Jun Ueda and Takayuki Tanaka and Akira Negi and Makoto Nakamura and Akiyasu Kanamori and Yuko Yamada and Akihiko Tawara and Toshiaki Kubota and Norihiko Tou and Tairo Kimura and Chiaki Furusawa and Naoki Inoue and Kiho Kawabata and Nobuhiko Tachibana and Akira Matsuda and Takahiko Seto and Satoshi Kimura and Satoki Ueno and Naoto Tokuda and Jun Inoue and Kazuhisa Sugiyama and Shinji Ohkubo and Kenya Yuki",
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T1 - Efficacy of predetermined therapeutic measures against bleb-related infection in the Collaborative Bleb-related Infection Incidence and Treatment Study

AU - the Collaborative Bleb-Related Infection Incidence and Treatment Study Group

AU - Shoji, Nobuyuki

AU - Arakaki, Yoshikuni

AU - Nakamoto, Kenji

AU - Yamamoto, Tetsuya

AU - Kuwayama, Yasuaki

AU - Aoyama, Yumiko

AU - Kawase, Kazuhide

AU - Ban, Takahiro

AU - Sawada, Akira

AU - Mochizuki, Kiyofumi

AU - Futa, Ryusuke

AU - Yasuda, Noriko

AU - Nakajima, Masayuki

AU - Sugiyama, Tetsuya

AU - Kojima, Shota

AU - Hirotsuji, Norihiko

AU - Kano, Kiyoshi

AU - Ohura, Atsushi

AU - Kawai, Eriko

AU - Nakata, Atsuko

AU - Kuwamura, Rika

AU - Okuno, Kensuke

AU - Yawata, Kenji

AU - Matsumoto, Shun

AU - Abe, Haruki

AU - Fukuchi, Takeo

AU - Shirakashi, Motohiro

AU - Ueda, Jun

AU - Tanaka, Takayuki

AU - Negi, Akira

AU - Nakamura, Makoto

AU - Kanamori, Akiyasu

AU - Yamada, Yuko

AU - Tawara, Akihiko

AU - Kubota, Toshiaki

AU - Tou, Norihiko

AU - Kimura, Tairo

AU - Furusawa, Chiaki

AU - Inoue, Naoki

AU - Kawabata, Kiho

AU - Tachibana, Nobuhiko

AU - Matsuda, Akira

AU - Seto, Takahiko

AU - Kimura, Satoshi

AU - Ueno, Satoki

AU - Tokuda, Naoto

AU - Inoue, Jun

AU - Sugiyama, Kazuhisa

AU - Ohkubo, Shinji

AU - Yuki, Kenya

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Purpose: To report the efficacy of the predetermined treatment protocol of the Collaborative Bleb-related Infection Incidence and Treatment Study (CBIITS) for bleb-related infection (BRI) patients. Methods: A prospective, observational cohort study was conducted at 34 clinical centres in Japan. Nineteen eyes from 19 patients that developed BRI were treated using the CBIITS protocol at 34 clinical centres. The visual acuity (VA) and intraocular pressure (IOP) were monitored for 6 and 12 months after treatment with the predetermined protocol. Results: The logMAR was 0.623 ± 0.748 (mean ± standard deviation) before the infection developed. It was 1.054 ± 1.156 and 0.950 ± 1.168 at 6 months and 12 months post-infection, respectively. However, in subgroup analyses, there was no significant decrease in post-infection logMAR in stages I and II. In contrast, decimal VA was decreased ≥2 lines in all four cases in stage III. The IOP did not change after infection. It was 10.2 ± 5.0 mmHg (range, 3–22 mmHg) before the infection developed, and 12.9 ± 5.2 mmHg (5–24 mmHg) and 10.7 ± 4.7 mmHg (3–18 mmHg) at 6 months and 12 months after infection, respectively. Conclusion: Because of the small number of BRI patients, the superiority of the treatment was not definitively determined. However, VA was almost maintained in stages I and II, and the IOP did not change after infection. Although further study is necessary, the treatment protocol shown in the study might be a valuable treatment regime.

AB - Purpose: To report the efficacy of the predetermined treatment protocol of the Collaborative Bleb-related Infection Incidence and Treatment Study (CBIITS) for bleb-related infection (BRI) patients. Methods: A prospective, observational cohort study was conducted at 34 clinical centres in Japan. Nineteen eyes from 19 patients that developed BRI were treated using the CBIITS protocol at 34 clinical centres. The visual acuity (VA) and intraocular pressure (IOP) were monitored for 6 and 12 months after treatment with the predetermined protocol. Results: The logMAR was 0.623 ± 0.748 (mean ± standard deviation) before the infection developed. It was 1.054 ± 1.156 and 0.950 ± 1.168 at 6 months and 12 months post-infection, respectively. However, in subgroup analyses, there was no significant decrease in post-infection logMAR in stages I and II. In contrast, decimal VA was decreased ≥2 lines in all four cases in stage III. The IOP did not change after infection. It was 10.2 ± 5.0 mmHg (range, 3–22 mmHg) before the infection developed, and 12.9 ± 5.2 mmHg (5–24 mmHg) and 10.7 ± 4.7 mmHg (3–18 mmHg) at 6 months and 12 months after infection, respectively. Conclusion: Because of the small number of BRI patients, the superiority of the treatment was not definitively determined. However, VA was almost maintained in stages I and II, and the IOP did not change after infection. Although further study is necessary, the treatment protocol shown in the study might be a valuable treatment regime.

KW - bleb-related infection

KW - blebitis

KW - predetermined treatment protocol

KW - trabeculectomy

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