Efficacy of S-flurbiprofen plaster in knee osteoarthritis treatment

Results from a phase III, randomized, active-controlled, adequate, and well-controlled trial

Ikuko Yataba, Noboru Otsuka, Isao Matsushita, Hideo Matsumoto, Yuichi Hoshino

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: S-flurbiprofen plaster (SFPP) is a novel non-steroidal anti-inflammatory drug (NSAID) patch, intended for topical treatment for musculoskeletal diseases. This trial was conducted to examine the effectiveness of SFPP using active comparator, flurbiprofen (FP) patch, on knee osteoarthritis (OA) symptoms. Methods: This was a phase III, multi-center, randomized, adequate, and well-controlled trial, both investigators and patients were blinded to the assigned treatment. Enrolled 633 knee OA patients were treated with either SFPP or FP patch for two weeks. The primary endpoint was improvement in knee pain on rising from the chair as assessed by visual analogue scale (rVAS). Safety was evaluated through adverse events (AEs). Results: The change in rVAS was 40.9 mm in SFPP group and 30.6 mm in FP patch group (p 

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalModern Rheumatology
DOIs
Publication statusAccepted/In press - 2016 May 5

Fingerprint

Flurbiprofen
Knee Osteoarthritis
Therapeutics
Musculoskeletal Diseases
Visual Analog Scale
Knee
Anti-Inflammatory Agents
Research Personnel
Safety
Pain

Keywords

  • Adequate and well-controlled trial
  • NSAIDs
  • Osteoarthritis
  • Pain
  • S-flurbiprofen

ASJC Scopus subject areas

  • Rheumatology

Cite this

Efficacy of S-flurbiprofen plaster in knee osteoarthritis treatment : Results from a phase III, randomized, active-controlled, adequate, and well-controlled trial. / Yataba, Ikuko; Otsuka, Noboru; Matsushita, Isao; Matsumoto, Hideo; Hoshino, Yuichi.

In: Modern Rheumatology, 05.05.2016, p. 1-7.

Research output: Contribution to journalArticle

@article{8593d2f3272745d59d02a5abd6423976,
title = "Efficacy of S-flurbiprofen plaster in knee osteoarthritis treatment: Results from a phase III, randomized, active-controlled, adequate, and well-controlled trial",
abstract = "Objectives: S-flurbiprofen plaster (SFPP) is a novel non-steroidal anti-inflammatory drug (NSAID) patch, intended for topical treatment for musculoskeletal diseases. This trial was conducted to examine the effectiveness of SFPP using active comparator, flurbiprofen (FP) patch, on knee osteoarthritis (OA) symptoms. Methods: This was a phase III, multi-center, randomized, adequate, and well-controlled trial, both investigators and patients were blinded to the assigned treatment. Enrolled 633 knee OA patients were treated with either SFPP or FP patch for two weeks. The primary endpoint was improvement in knee pain on rising from the chair as assessed by visual analogue scale (rVAS). Safety was evaluated through adverse events (AEs). Results: The change in rVAS was 40.9 mm in SFPP group and 30.6 mm in FP patch group (p ",
keywords = "Adequate and well-controlled trial, NSAIDs, Osteoarthritis, Pain, S-flurbiprofen",
author = "Ikuko Yataba and Noboru Otsuka and Isao Matsushita and Hideo Matsumoto and Yuichi Hoshino",
year = "2016",
month = "5",
day = "5",
doi = "10.1080/14397595.2016.1176624",
language = "English",
pages = "1--7",
journal = "Modern Rheumatology",
issn = "1439-7595",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Efficacy of S-flurbiprofen plaster in knee osteoarthritis treatment

T2 - Results from a phase III, randomized, active-controlled, adequate, and well-controlled trial

AU - Yataba, Ikuko

AU - Otsuka, Noboru

AU - Matsushita, Isao

AU - Matsumoto, Hideo

AU - Hoshino, Yuichi

PY - 2016/5/5

Y1 - 2016/5/5

N2 - Objectives: S-flurbiprofen plaster (SFPP) is a novel non-steroidal anti-inflammatory drug (NSAID) patch, intended for topical treatment for musculoskeletal diseases. This trial was conducted to examine the effectiveness of SFPP using active comparator, flurbiprofen (FP) patch, on knee osteoarthritis (OA) symptoms. Methods: This was a phase III, multi-center, randomized, adequate, and well-controlled trial, both investigators and patients were blinded to the assigned treatment. Enrolled 633 knee OA patients were treated with either SFPP or FP patch for two weeks. The primary endpoint was improvement in knee pain on rising from the chair as assessed by visual analogue scale (rVAS). Safety was evaluated through adverse events (AEs). Results: The change in rVAS was 40.9 mm in SFPP group and 30.6 mm in FP patch group (p 

AB - Objectives: S-flurbiprofen plaster (SFPP) is a novel non-steroidal anti-inflammatory drug (NSAID) patch, intended for topical treatment for musculoskeletal diseases. This trial was conducted to examine the effectiveness of SFPP using active comparator, flurbiprofen (FP) patch, on knee osteoarthritis (OA) symptoms. Methods: This was a phase III, multi-center, randomized, adequate, and well-controlled trial, both investigators and patients were blinded to the assigned treatment. Enrolled 633 knee OA patients were treated with either SFPP or FP patch for two weeks. The primary endpoint was improvement in knee pain on rising from the chair as assessed by visual analogue scale (rVAS). Safety was evaluated through adverse events (AEs). Results: The change in rVAS was 40.9 mm in SFPP group and 30.6 mm in FP patch group (p 

KW - Adequate and well-controlled trial

KW - NSAIDs

KW - Osteoarthritis

KW - Pain

KW - S-flurbiprofen

UR - http://www.scopus.com/inward/record.url?scp=84966700315&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966700315&partnerID=8YFLogxK

U2 - 10.1080/14397595.2016.1176624

DO - 10.1080/14397595.2016.1176624

M3 - Article

SP - 1

EP - 7

JO - Modern Rheumatology

JF - Modern Rheumatology

SN - 1439-7595

ER -