Efficiency of protective isolation in allogeneic stem cell transplantation in children

Hiroshi Matsubara, Atsushi Makimoto, Mutsuro Ohira, Yoshinobu Kanda, Masahiro Kami, Ryuji Tanosaki, Shin Mineishi, Youichi Takaue

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Forty children with hematological malignancies, who underwent allogeneic hematopoietic stem cell transplants between September 1994 and May 2001, were divided into 2 groups according to their infection control procedure; the standard protective isolation and the efficient protective isolation groups. Efficient protective isolation procedures included well-cooked foods and oral prophylaxis with new quinolones and antifungal drugs, while inhalation of antibiotics and antifungal drugs was suspended. We then compared the febrile index (= X/Y) [febrile period (X) of > 38.5 degrees C and the days (Y) with a post-transplant neutrophil count < 500/microliter] between the two groups. We discovered no significant difference between the febrile index of the two groups (0.25 vs. 0.38, p = 0.08), regardless of the type of transplantation (0.36 vs. 0.38, p = 0.14). The efficient protective isolation procedure was therefore feasible in this clinical setting.

Original languageEnglish
Pages (from-to)520-526
Number of pages7
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume43
Issue number7
Publication statusPublished - 2002
Externally publishedYes

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Stem Cell Transplantation
Fever
Inhalation Administration
Transplants
Antifungal Agents
Quinolones
Hematologic Neoplasms
Infection Control
Hematopoietic Stem Cells
Neutrophils
Transplantation
Food
Pharmaceutical Preparations

Cite this

Efficiency of protective isolation in allogeneic stem cell transplantation in children. / Matsubara, Hiroshi; Makimoto, Atsushi; Ohira, Mutsuro; Kanda, Yoshinobu; Kami, Masahiro; Tanosaki, Ryuji; Mineishi, Shin; Takaue, Youichi.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 43, No. 7, 2002, p. 520-526.

Research output: Contribution to journalArticle

Matsubara, H, Makimoto, A, Ohira, M, Kanda, Y, Kami, M, Tanosaki, R, Mineishi, S & Takaue, Y 2002, 'Efficiency of protective isolation in allogeneic stem cell transplantation in children', [Rinshō ketsueki] The Japanese journal of clinical hematology, vol. 43, no. 7, pp. 520-526.
Matsubara, Hiroshi ; Makimoto, Atsushi ; Ohira, Mutsuro ; Kanda, Yoshinobu ; Kami, Masahiro ; Tanosaki, Ryuji ; Mineishi, Shin ; Takaue, Youichi. / Efficiency of protective isolation in allogeneic stem cell transplantation in children. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 2002 ; Vol. 43, No. 7. pp. 520-526.
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AU - Tanosaki, Ryuji

AU - Mineishi, Shin

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