TY - GEN
T1 - Efficient Gas-to-Liquid Partition Using Gas-Flow Channels for Cell-Based Gaseous Odorant Detection
AU - Nakane, Takuma
AU - Osaki, Toshihisa
AU - Mimura, Hisatoshi
AU - Miki, Norihisa
AU - Takeuchi, Shoji
N1 - Funding Information:
This work was partly supported by JST CREST Grant Number JPMJCR20C4, and the Program for Building Regional Innovation Ecosystem of MEXT, Japan. We thank Ms. Kikuchi (KISTEC) for the technical support.
Publisher Copyright:
© 2021 IEEE.
PY - 2021/6/20
Y1 - 2021/6/20
N2 - Cell-based sensors using olfactory receptors have attracted attention because of their high sensitivity and selectivity. A challenge is efficient partition of gaseous samples to the aqueous solution where the cell-based sensors reside. In this paper, we developed a device with a gas-flow channel, which allowed inflow of gaseous odorants over a well filled with aqueous solution. We considered that shear stress induced by the gas-flow at the gas-liquid interface initiate convectional mixing inside liquid and in turn, promotes partitioning of gaseous odorants into the solution. Solubility of a gaseous odorant was experimentally found to increase with the mixing strength. We further demonstrated efficient detection of a gaseous odorant using the sensor cells with the developed gas-flow device.
AB - Cell-based sensors using olfactory receptors have attracted attention because of their high sensitivity and selectivity. A challenge is efficient partition of gaseous samples to the aqueous solution where the cell-based sensors reside. In this paper, we developed a device with a gas-flow channel, which allowed inflow of gaseous odorants over a well filled with aqueous solution. We considered that shear stress induced by the gas-flow at the gas-liquid interface initiate convectional mixing inside liquid and in turn, promotes partitioning of gaseous odorants into the solution. Solubility of a gaseous odorant was experimentally found to increase with the mixing strength. We further demonstrated efficient detection of a gaseous odorant using the sensor cells with the developed gas-flow device.
KW - Cell-based sensor
KW - Gas-to-liquid partition
KW - Gaseous odorant
KW - Insect olfactory receptor
KW - Odorant sensor
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U2 - 10.1109/Transducers50396.2021.9495472
DO - 10.1109/Transducers50396.2021.9495472
M3 - Conference contribution
AN - SCOPUS:85114962912
T3 - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
SP - 763
EP - 766
BT - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
Y2 - 20 June 2021 through 25 June 2021
ER -