Efficient parameter identification for stochastic biochemical networks using a reduced-order realization

Yutaka Hori, Mustafa H. Khammash, Shinji Hara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

In this paper, we propose a parameter identification method for stochastic biochemical reaction networks using flow cytometry data. A distinctive feature of the proposed method is that it is computationally efficient compared to existing works, thus it is applicable to complex biochemical networks. To this end, we first show that it is possible to construct a significantly small-order realization of the stochastic biochemical system using flow cytometry measurements. Then, the small-order realization is utilized for the development of the efficient identification method. Finally, the proposed method is demonstrated with an existing biological example.

Original languageEnglish
Title of host publication2013 European Control Conference, ECC 2013
Pages4154-4159
Number of pages6
Publication statusPublished - 2013
Externally publishedYes
Event2013 12th European Control Conference, ECC 2013 - Zurich, Switzerland
Duration: 2013 Jul 172013 Jul 19

Other

Other2013 12th European Control Conference, ECC 2013
CountrySwitzerland
CityZurich
Period13/7/1713/7/19

Fingerprint

Flow cytometry
Identification (control systems)

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Hori, Y., Khammash, M. H., & Hara, S. (2013). Efficient parameter identification for stochastic biochemical networks using a reduced-order realization. In 2013 European Control Conference, ECC 2013 (pp. 4154-4159). [6669455]

Efficient parameter identification for stochastic biochemical networks using a reduced-order realization. / Hori, Yutaka; Khammash, Mustafa H.; Hara, Shinji.

2013 European Control Conference, ECC 2013. 2013. p. 4154-4159 6669455.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hori, Y, Khammash, MH & Hara, S 2013, Efficient parameter identification for stochastic biochemical networks using a reduced-order realization. in 2013 European Control Conference, ECC 2013., 6669455, pp. 4154-4159, 2013 12th European Control Conference, ECC 2013, Zurich, Switzerland, 13/7/17.
Hori Y, Khammash MH, Hara S. Efficient parameter identification for stochastic biochemical networks using a reduced-order realization. In 2013 European Control Conference, ECC 2013. 2013. p. 4154-4159. 6669455
Hori, Yutaka ; Khammash, Mustafa H. ; Hara, Shinji. / Efficient parameter identification for stochastic biochemical networks using a reduced-order realization. 2013 European Control Conference, ECC 2013. 2013. pp. 4154-4159
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