Efficient preparation of 4-hydroxyquinolin-2(1 H)-one derivatives with silver-catalyzed carbon dioxide incorporation and intramolecular rearrangement

Tomonobu Ishida, Satoshi Kikuchi, Tohru Yamada

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Although 4-hydroxyquinolin-2(1H)-one derivatives have attracted much attention due to their biological benefits, conventional reactions under harsh heat conditions must be employed to provide these key compounds. In the presence of a catalytic amount of silver salt, various o-alkynylanilines were treated with carbon dioxide and a base under mild reaction conditions to afford the corresponding 4-hydroxyquinolin-2(1H)-one derivatives in high yield.

Original languageEnglish
Pages (from-to)3710-3713
Number of pages4
JournalOrganic Letters
Volume15
Issue number14
DOIs
Publication statusPublished - 2013 Jul 19

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Silver
Carbon Dioxide
carbon dioxide
silver
Derivatives
preparation
Salts
Hot Temperature
salts
heat
4-hydroxyquinoline
4-hydroxyquinolin-2(1H)-one

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Efficient preparation of 4-hydroxyquinolin-2(1 H)-one derivatives with silver-catalyzed carbon dioxide incorporation and intramolecular rearrangement. / Ishida, Tomonobu; Kikuchi, Satoshi; Yamada, Tohru.

In: Organic Letters, Vol. 15, No. 14, 19.07.2013, p. 3710-3713.

Research output: Contribution to journalArticle

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