EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy

J. Guillermo Paez, Pasi A. Jänne, Jeffrey C. Lee, Sean Tracy, Heidi Greulich, Stacey Gabriel, Paula Herman, Frederic J. Kaye, Neal Lindeman, Titus J. Boggon, Katsuhiko Naoki, Hidefumini Sasaki, Yoshitaka Fujii, Michael J. Eck, William R. Sellers, Bruce E. Johnson, Matthew Meyerson

Research output: Contribution to journalArticle

7567 Citations (Scopus)

Abstract

Receptor tyrosine kinase genes were sequenced in non-small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGFR were found in 15 of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment with the EGFR kinase inhibitor gefitinib (Iressa) causes tumor regression in some patients with NSCLC, more frequently in Japan. EGFR mutations were found in additional lung cancer samples from U.S. patients who responded to gefitinib therapy and in a lung adenocarcinoma cell line that was hypersensitive to growth inhibition by gefitinib, but not in gefitinib-insensitive tumors or cell lines. These results suggest that EGFR mutations may predict sensitivity to gefitinib.

Original languageEnglish
Pages (from-to)1497-1500
Number of pages4
JournalScience
Volume304
Issue number5676
DOIs
Publication statusPublished - 2004 Jun 4
Externally publishedYes

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Lung Neoplasms
Mutation
Non-Small Cell Lung Carcinoma
Japan
Therapeutics
erbB-1 Genes
Receptor Protein-Tyrosine Kinases
Tumor Cell Line
gefitinib
Neoplasms
Phosphotransferases
Cell Line
Growth
Genes

ASJC Scopus subject areas

  • General

Cite this

Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., ... Meyerson, M. (2004). EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy. Science, 304(5676), 1497-1500. https://doi.org/10.1126/science.1099314

EGFR mutations in lung, cancer : Correlation with clinical response to gefitinib therapy. / Paez, J. Guillermo; Jänne, Pasi A.; Lee, Jeffrey C.; Tracy, Sean; Greulich, Heidi; Gabriel, Stacey; Herman, Paula; Kaye, Frederic J.; Lindeman, Neal; Boggon, Titus J.; Naoki, Katsuhiko; Sasaki, Hidefumini; Fujii, Yoshitaka; Eck, Michael J.; Sellers, William R.; Johnson, Bruce E.; Meyerson, Matthew.

In: Science, Vol. 304, No. 5676, 04.06.2004, p. 1497-1500.

Research output: Contribution to journalArticle

Paez, JG, Jänne, PA, Lee, JC, Tracy, S, Greulich, H, Gabriel, S, Herman, P, Kaye, FJ, Lindeman, N, Boggon, TJ, Naoki, K, Sasaki, H, Fujii, Y, Eck, MJ, Sellers, WR, Johnson, BE & Meyerson, M 2004, 'EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy', Science, vol. 304, no. 5676, pp. 1497-1500. https://doi.org/10.1126/science.1099314
Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S et al. EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy. Science. 2004 Jun 4;304(5676):1497-1500. https://doi.org/10.1126/science.1099314
Paez, J. Guillermo ; Jänne, Pasi A. ; Lee, Jeffrey C. ; Tracy, Sean ; Greulich, Heidi ; Gabriel, Stacey ; Herman, Paula ; Kaye, Frederic J. ; Lindeman, Neal ; Boggon, Titus J. ; Naoki, Katsuhiko ; Sasaki, Hidefumini ; Fujii, Yoshitaka ; Eck, Michael J. ; Sellers, William R. ; Johnson, Bruce E. ; Meyerson, Matthew. / EGFR mutations in lung, cancer : Correlation with clinical response to gefitinib therapy. In: Science. 2004 ; Vol. 304, No. 5676. pp. 1497-1500.
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