Eiger and wengen

The drosophila orthologs of TNF/TNFR

Tatsushi Igaki, Hiroshi Kanda, Hideyuki Okano, Tian Xu, Masayuki Miura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Drosophila provides a powerful genetic model for studying the in vivo regulation of biological processes, such as cell proliferation, cell differentiation, and cell death. In a large-scale ectopic-expression screen in Drosophila for identifying genes regulating cell death, the fly homolog of tumor necrosis factor (TNF) encoded by eiger (e da-l i ke cell death trig ger) was identified [7]. eiger was also isolated independently through a molecular approach [15]. eiger encodes a protein of 409 amino acids with a C-terminal TNF homology domain and a hydrophobic transmembrane domain. The sequence of the Eiger's TNF domain shows highest homology with human EDA-A2 (28%) and also shows significant homology with all known mammalian TNF superfamily members.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages45-50
Number of pages6
Volume691
DOIs
Publication statusPublished - 2011

Publication series

NameAdvances in Experimental Medicine and Biology
Volume691
ISSN (Print)00652598

Fingerprint

Drosophila
Cell Death
Cell death
Tumor Necrosis Factor-alpha
Lymphotoxin-beta
Biological Phenomena
Genetic Models
varespladib methyl
Diptera
Cell Differentiation
Cell proliferation
Cell Proliferation
Amino Acids
Genes
Proteins
Ectopic Gene Expression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Igaki, T., Kanda, H., Okano, H., Xu, T., & Miura, M. (2011). Eiger and wengen: The drosophila orthologs of TNF/TNFR. In Advances in Experimental Medicine and Biology (Vol. 691, pp. 45-50). (Advances in Experimental Medicine and Biology; Vol. 691). https://doi.org/10.1007/978-1-4419-6612-4_5

Eiger and wengen : The drosophila orthologs of TNF/TNFR. / Igaki, Tatsushi; Kanda, Hiroshi; Okano, Hideyuki; Xu, Tian; Miura, Masayuki.

Advances in Experimental Medicine and Biology. Vol. 691 2011. p. 45-50 (Advances in Experimental Medicine and Biology; Vol. 691).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Igaki, T, Kanda, H, Okano, H, Xu, T & Miura, M 2011, Eiger and wengen: The drosophila orthologs of TNF/TNFR. in Advances in Experimental Medicine and Biology. vol. 691, Advances in Experimental Medicine and Biology, vol. 691, pp. 45-50. https://doi.org/10.1007/978-1-4419-6612-4_5
Igaki T, Kanda H, Okano H, Xu T, Miura M. Eiger and wengen: The drosophila orthologs of TNF/TNFR. In Advances in Experimental Medicine and Biology. Vol. 691. 2011. p. 45-50. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-6612-4_5
Igaki, Tatsushi ; Kanda, Hiroshi ; Okano, Hideyuki ; Xu, Tian ; Miura, Masayuki. / Eiger and wengen : The drosophila orthologs of TNF/TNFR. Advances in Experimental Medicine and Biology. Vol. 691 2011. pp. 45-50 (Advances in Experimental Medicine and Biology).
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