Eight-year follow-up of patients with immune thrombocytopenic purpura related toH. pyloriinfection.

Taku Kikuchi, Takeshi Kobayashi, Takuya Yamashita, Kazuteru Ohashi, Hisashi Sakamaki, Hideki Akiyama

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Thrombocytopenia related to Helicobacter pylori infection is a definitive subset of chronic immune thrombocytopenic purpura (ITP) but its long-term prognosis has not been evaluated extensively. The possibility of recurrence of thrombocytopenia after re-infection of H. pylori is another concern. We evaluated 8-year follow-up data for 11 patients with ITP related to H. pylori infection in a single institution. In 2001, patients with chronic ITP were evaluated for H. pylori infection at the Tokyo Metropolitan Komagome Hospital using 13C urea breath test (UBIT). Nineteen patients turned out to be positive and were treated for H. pylori infection. Platelet count 6 months after treatment revealed complete response (CR) in 10 patients and response in one patient. Eight years later, 17 of these 19 patients were re-evaluated for H. pylori infection and platelet count. Platelet counts of the 11 previous responders remained to indicate CR. Two of 13 patients re-examined by UBIT showed positive results and one of these two patients continued to keep normal platelet count. Nonetheless, the prognosis of patients who responded to eradication was excellent.

Original languageEnglish
Pages (from-to)59-62
Number of pages4
JournalPlatelets
Volume22
Issue number1
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Idiopathic Thrombocytopenic Purpura
Helicobacter pylori
Helicobacter Infections
Platelet Count
Thrombocytopenia
Breath Tests
Tokyo
Urban Hospitals
Urea
Recurrence

ASJC Scopus subject areas

  • Hematology

Cite this

Eight-year follow-up of patients with immune thrombocytopenic purpura related toH. pyloriinfection. / Kikuchi, Taku; Kobayashi, Takeshi; Yamashita, Takuya; Ohashi, Kazuteru; Sakamaki, Hisashi; Akiyama, Hideki.

In: Platelets, Vol. 22, No. 1, 2011, p. 59-62.

Research output: Contribution to journalArticle

Kikuchi, Taku ; Kobayashi, Takeshi ; Yamashita, Takuya ; Ohashi, Kazuteru ; Sakamaki, Hisashi ; Akiyama, Hideki. / Eight-year follow-up of patients with immune thrombocytopenic purpura related toH. pyloriinfection. In: Platelets. 2011 ; Vol. 22, No. 1. pp. 59-62.
@article{a26e3f9de6134c7d8212c1498ffaf134,
title = "Eight-year follow-up of patients with immune thrombocytopenic purpura related toH. pyloriinfection.",
abstract = "Thrombocytopenia related to Helicobacter pylori infection is a definitive subset of chronic immune thrombocytopenic purpura (ITP) but its long-term prognosis has not been evaluated extensively. The possibility of recurrence of thrombocytopenia after re-infection of H. pylori is another concern. We evaluated 8-year follow-up data for 11 patients with ITP related to H. pylori infection in a single institution. In 2001, patients with chronic ITP were evaluated for H. pylori infection at the Tokyo Metropolitan Komagome Hospital using 13C urea breath test (UBIT). Nineteen patients turned out to be positive and were treated for H. pylori infection. Platelet count 6 months after treatment revealed complete response (CR) in 10 patients and response in one patient. Eight years later, 17 of these 19 patients were re-evaluated for H. pylori infection and platelet count. Platelet counts of the 11 previous responders remained to indicate CR. Two of 13 patients re-examined by UBIT showed positive results and one of these two patients continued to keep normal platelet count. Nonetheless, the prognosis of patients who responded to eradication was excellent.",
author = "Taku Kikuchi and Takeshi Kobayashi and Takuya Yamashita and Kazuteru Ohashi and Hisashi Sakamaki and Hideki Akiyama",
year = "2011",
doi = "10.3109/09537104.2010.515272",
language = "English",
volume = "22",
pages = "59--62",
journal = "Platelets",
issn = "0953-7104",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Eight-year follow-up of patients with immune thrombocytopenic purpura related toH. pyloriinfection.

AU - Kikuchi, Taku

AU - Kobayashi, Takeshi

AU - Yamashita, Takuya

AU - Ohashi, Kazuteru

AU - Sakamaki, Hisashi

AU - Akiyama, Hideki

PY - 2011

Y1 - 2011

N2 - Thrombocytopenia related to Helicobacter pylori infection is a definitive subset of chronic immune thrombocytopenic purpura (ITP) but its long-term prognosis has not been evaluated extensively. The possibility of recurrence of thrombocytopenia after re-infection of H. pylori is another concern. We evaluated 8-year follow-up data for 11 patients with ITP related to H. pylori infection in a single institution. In 2001, patients with chronic ITP were evaluated for H. pylori infection at the Tokyo Metropolitan Komagome Hospital using 13C urea breath test (UBIT). Nineteen patients turned out to be positive and were treated for H. pylori infection. Platelet count 6 months after treatment revealed complete response (CR) in 10 patients and response in one patient. Eight years later, 17 of these 19 patients were re-evaluated for H. pylori infection and platelet count. Platelet counts of the 11 previous responders remained to indicate CR. Two of 13 patients re-examined by UBIT showed positive results and one of these two patients continued to keep normal platelet count. Nonetheless, the prognosis of patients who responded to eradication was excellent.

AB - Thrombocytopenia related to Helicobacter pylori infection is a definitive subset of chronic immune thrombocytopenic purpura (ITP) but its long-term prognosis has not been evaluated extensively. The possibility of recurrence of thrombocytopenia after re-infection of H. pylori is another concern. We evaluated 8-year follow-up data for 11 patients with ITP related to H. pylori infection in a single institution. In 2001, patients with chronic ITP were evaluated for H. pylori infection at the Tokyo Metropolitan Komagome Hospital using 13C urea breath test (UBIT). Nineteen patients turned out to be positive and were treated for H. pylori infection. Platelet count 6 months after treatment revealed complete response (CR) in 10 patients and response in one patient. Eight years later, 17 of these 19 patients were re-evaluated for H. pylori infection and platelet count. Platelet counts of the 11 previous responders remained to indicate CR. Two of 13 patients re-examined by UBIT showed positive results and one of these two patients continued to keep normal platelet count. Nonetheless, the prognosis of patients who responded to eradication was excellent.

UR - http://www.scopus.com/inward/record.url?scp=79959802520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959802520&partnerID=8YFLogxK

U2 - 10.3109/09537104.2010.515272

DO - 10.3109/09537104.2010.515272

M3 - Article

VL - 22

SP - 59

EP - 62

JO - Platelets

JF - Platelets

SN - 0953-7104

IS - 1

ER -