@article{bab35de9d736417c9b0a705796d987bc,
title = "Electric field causes volumetric changes in the human brain",
abstract = "Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t =3.77, df = 83, r = 0.38, p = 0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.",
author = "Miklos Argyelan and Leif Oltedal and Deng, {Zhi De} and Benjamin Wade and Marom Bikson and Andrea Joanlanne and Sohag Sanghani and Hauke Bartsch and Marta Cano and {Dale Anders}, M. and Udo Dannlowski and Annemiek Dols and Verena Enneking and Randall Espinoza and Ute Kessler and {Narr Katherine}, L. and {Oedegaard Ketil}, J. and {Oudega Mardien}, L. and Ronny Redlich and {Stek Max}, L. and Akihiro Takamiya and Louise Emsell and Filip Bouckaert and Pascal Sienaert and Jesus Pujol and Indira Tendolkar and {van Eijndhoven}, Philip and Georgios Petrides and {Malhotra Anil}, K. and Christopher Abbott",
note = "Funding Information: This work was supported by the Western Norway Regional Health Authority (#911986 to KJO and # 912238 to LO) and the University of Bergen, Norway, the Fulbright Program (to LO); the National Institute of Mental Health (#MH092301, #MH110008, #MH102743) (to KN and RE), #MH119616 (to MA), #MH111826 (to CA) and the German Research Foundation (DFG FOR2107 DA1151/5-1 and DA1151/5-2 ; SFB-TRR58, Projects C09 and Z02) (UD) and Innovative medical research (RE111604, RE111722)(to RR). ZD is supported by the National Institute of Mental Health Intramural Research Program (ZIAMH00295). Funding Information: This work was supported by the Western Norway Regional Health Authority (#911986 to KJO and # 912238 to LO) and the University of Bergen, Norway, the Fulbright Program (to LO); the National Institute of Mental Health (#MH092301, #MH110008, #MH102743) (to KN and RE), #MH119616 (to MA), #MH111826 (to CA) and the German Research Foundation (DFG FOR2107 DA1151/5-1 and DA1151/5-2; SFB-TRR58, Projects C09 and Z02) (UD) and Innovative medical research (RE111604, RE111722)(to RR). ZD is supported by the National Institute of Mental Health Intramural Research Program (ZIAMH00295). We would like to acknowledge the logistic and academic support of the whole GEMRIC consortium outside of the authorship of this manuscript. These collaborators were not only actively involved in this manuscript but their valuable feedback on our regular meetings contributed to this manuscript in many levels. The full overview of the GEMRIC board members can be find here: https://helse-bergen.no/en/avdelinger/psykisk-helsevern/forskingsavdelinga-divisjon-psykisk-helsevern/gemric-the-global-ect-mri-research-collaboration/gemric-the-global-ectmri-research-collaboration. Publisher Copyright: {\textcopyright} 2019, eLife Sciences Publications Ltd. All rights reserved.",
year = "2019",
month = oct,
doi = "10.7554/eLife.49115",
language = "English",
volume = "8",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}