Electrical storm in patients with Brugada syndrome is associated with early repolarization

Yoshiaki Kaneko, Minoru Horie, Shinichi Niwano, Kengo F. Kusano, Seiji Takatsuki, Takashi Kurita, Takeshi Mitsuhashi, Tadashi Nakajima, Tadanobu Irie, Kanae Hasegawa, Takashi Noda, Shiro Kamakura, Yoshiyasu Aizawa, Ryobun Yasuoka, Katsumi Torigoe, Hiroshi Suzuki, Toru Ohe, Akihiko Shimizu, Keiichi Fukuda, Masahiko KurabayashiYoshifusa Aizawa

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43 Citations (Scopus)

Abstract

Background: Electrical storms (ESs) in patients with Brugada syndrome (BrS) are rare though potentially lethal. Methods and Results: We studied 22 men with BrS and ES, defined as ≥3 episodes/d of ventricular fibrillation (VF) and compared their characteristics with those of 110 age-matched, control men with BrS without ES. BrS was diagnosed by a spontaneous or drug-induced type 1 pattern on the ECG in the absence of structural heart disease. Early repolarization (ER) was diagnosed by J waves, ie, >0.1 mV notches or slurs of the terminal portion of the QRS complex. The BrS ECG pattern was provoked with pilsicainide. A spontaneous type I ECG pattern, J waves, and horizontal/descending ST elevation were found, respectively, in 77%, 36%, and 88% of patients with ES, versus 28% (P<0.0001), 9% (P=0.003), and 60% (P=0.06) of controls. The J-wave amplitude was significantly higher in patients with than without ES (P=0.03). VF occurred during undisturbed sinus rhythm in 14 of 19 patients (74%), and ES were controlled by isoproterenol administration. All patients with ES received an implantable cardioverter defibrillator and over a 6.0±5.4 years followup, the prognosis of patients with ES was significantly worse than that of patients without ES. Bepridil was effective in preventing VF in 6 patients. Conclusions: A high prevalence of ER was found in a subgroup of patients with BrS associated with ES. ES appeared to be suppressed by isoproterenol or quinidine, whereas bepridil and quinidine were effective in the long-term prevention of VF in the highest-risk patients.

Original languageEnglish
Pages (from-to)1122-1128
Number of pages7
JournalCirculation: Arrhythmia and Electrophysiology
Volume7
Issue number6
DOIs
Publication statusPublished - 2014 Dec 1

Keywords

  • Bepridil
  • Brugada syndrome
  • Electrocardiography
  • Isoproterenol
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Kaneko, Y., Horie, M., Niwano, S., Kusano, K. F., Takatsuki, S., Kurita, T., Mitsuhashi, T., Nakajima, T., Irie, T., Hasegawa, K., Noda, T., Kamakura, S., Aizawa, Y., Yasuoka, R., Torigoe, K., Suzuki, H., Ohe, T., Shimizu, A., Fukuda, K., ... Aizawa, Y. (2014). Electrical storm in patients with Brugada syndrome is associated with early repolarization. Circulation: Arrhythmia and Electrophysiology, 7(6), 1122-1128. https://doi.org/10.1161/CIRCEP.114.001806