Electrochemical measurement of lamotrigine using boron-doped diamond electrodes

Ai Hanawa, Kai Asai, Genki Ogata, Hiroshi Hibino, Yasuaki Einaga

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this paper we report on a study of the electrochemical behavior of lamotrigine (LTG) using boron-doped diamond (BDD) electrodes. Cyclic voltammetry of LTG in a phosphate buffer solution exhibited an oxidation signal at ca. +1.4 V (vs. Ag/AgCl). A reduction signal at −0.5 to −1.0 V (vs. Ag/AgCl) was observed only after oxidation of LTG. The oxidation signal was due to polymerization of LTG adsorbed on the BDD electrode, while the reduction signal was a consequence of a process involving the reduction of the azo group in the LTG-oxidized product. Continuous measurements of LTG aiming at in vivo monitoring were successfully investigated and an optimized chronoamperometry technique, in which the BDD microelectrode was clamped to the LTG oxidation potential (+1.4 V) for 2 s, then to the LTG reduction potential (−0.6 V) for 2 s, was implemented. The limits of detection (S/N = 3) were estimated to be 29 nM and 130 nM for the oxidation and reduction of LTG, respectively. The use of this chronoamperometry technique enables a high temporal resolution of 4 s for LTG measurements. BDD microelectrodes, therefore, are the ideal electrodes for performing continuous in vivo measurements of LTG.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalElectrochimica Acta
Volume271
DOIs
Publication statusPublished - 2018 May 1

Fingerprint

Diamond
Boron
Diamonds
Oxidation
Electrodes
Chronoamperometry
Microelectrodes
Cyclic voltammetry
Phosphates
Polymerization
lamotrigine
Monitoring
Buffers

Keywords

  • Boron-doped diamond
  • Chronoamperometry
  • Cyclic voltammetry
  • Lamotrigine
  • Microelectrode

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Electrochemistry

Cite this

Electrochemical measurement of lamotrigine using boron-doped diamond electrodes. / Hanawa, Ai; Asai, Kai; Ogata, Genki; Hibino, Hiroshi; Einaga, Yasuaki.

In: Electrochimica Acta, Vol. 271, 01.05.2018, p. 35-40.

Research output: Contribution to journalArticle

Hanawa, Ai ; Asai, Kai ; Ogata, Genki ; Hibino, Hiroshi ; Einaga, Yasuaki. / Electrochemical measurement of lamotrigine using boron-doped diamond electrodes. In: Electrochimica Acta. 2018 ; Vol. 271. pp. 35-40.
@article{21fb7068fa3a446fb517f525ff74b709,
title = "Electrochemical measurement of lamotrigine using boron-doped diamond electrodes",
abstract = "In this paper we report on a study of the electrochemical behavior of lamotrigine (LTG) using boron-doped diamond (BDD) electrodes. Cyclic voltammetry of LTG in a phosphate buffer solution exhibited an oxidation signal at ca. +1.4 V (vs. Ag/AgCl). A reduction signal at −0.5 to −1.0 V (vs. Ag/AgCl) was observed only after oxidation of LTG. The oxidation signal was due to polymerization of LTG adsorbed on the BDD electrode, while the reduction signal was a consequence of a process involving the reduction of the azo group in the LTG-oxidized product. Continuous measurements of LTG aiming at in vivo monitoring were successfully investigated and an optimized chronoamperometry technique, in which the BDD microelectrode was clamped to the LTG oxidation potential (+1.4 V) for 2 s, then to the LTG reduction potential (−0.6 V) for 2 s, was implemented. The limits of detection (S/N = 3) were estimated to be 29 nM and 130 nM for the oxidation and reduction of LTG, respectively. The use of this chronoamperometry technique enables a high temporal resolution of 4 s for LTG measurements. BDD microelectrodes, therefore, are the ideal electrodes for performing continuous in vivo measurements of LTG.",
keywords = "Boron-doped diamond, Chronoamperometry, Cyclic voltammetry, Lamotrigine, Microelectrode",
author = "Ai Hanawa and Kai Asai and Genki Ogata and Hiroshi Hibino and Yasuaki Einaga",
year = "2018",
month = "5",
day = "1",
doi = "10.1016/j.electacta.2018.03.112",
language = "English",
volume = "271",
pages = "35--40",
journal = "Electrochimica Acta",
issn = "0013-4686",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Electrochemical measurement of lamotrigine using boron-doped diamond electrodes

AU - Hanawa, Ai

AU - Asai, Kai

AU - Ogata, Genki

AU - Hibino, Hiroshi

AU - Einaga, Yasuaki

PY - 2018/5/1

Y1 - 2018/5/1

N2 - In this paper we report on a study of the electrochemical behavior of lamotrigine (LTG) using boron-doped diamond (BDD) electrodes. Cyclic voltammetry of LTG in a phosphate buffer solution exhibited an oxidation signal at ca. +1.4 V (vs. Ag/AgCl). A reduction signal at −0.5 to −1.0 V (vs. Ag/AgCl) was observed only after oxidation of LTG. The oxidation signal was due to polymerization of LTG adsorbed on the BDD electrode, while the reduction signal was a consequence of a process involving the reduction of the azo group in the LTG-oxidized product. Continuous measurements of LTG aiming at in vivo monitoring were successfully investigated and an optimized chronoamperometry technique, in which the BDD microelectrode was clamped to the LTG oxidation potential (+1.4 V) for 2 s, then to the LTG reduction potential (−0.6 V) for 2 s, was implemented. The limits of detection (S/N = 3) were estimated to be 29 nM and 130 nM for the oxidation and reduction of LTG, respectively. The use of this chronoamperometry technique enables a high temporal resolution of 4 s for LTG measurements. BDD microelectrodes, therefore, are the ideal electrodes for performing continuous in vivo measurements of LTG.

AB - In this paper we report on a study of the electrochemical behavior of lamotrigine (LTG) using boron-doped diamond (BDD) electrodes. Cyclic voltammetry of LTG in a phosphate buffer solution exhibited an oxidation signal at ca. +1.4 V (vs. Ag/AgCl). A reduction signal at −0.5 to −1.0 V (vs. Ag/AgCl) was observed only after oxidation of LTG. The oxidation signal was due to polymerization of LTG adsorbed on the BDD electrode, while the reduction signal was a consequence of a process involving the reduction of the azo group in the LTG-oxidized product. Continuous measurements of LTG aiming at in vivo monitoring were successfully investigated and an optimized chronoamperometry technique, in which the BDD microelectrode was clamped to the LTG oxidation potential (+1.4 V) for 2 s, then to the LTG reduction potential (−0.6 V) for 2 s, was implemented. The limits of detection (S/N = 3) were estimated to be 29 nM and 130 nM for the oxidation and reduction of LTG, respectively. The use of this chronoamperometry technique enables a high temporal resolution of 4 s for LTG measurements. BDD microelectrodes, therefore, are the ideal electrodes for performing continuous in vivo measurements of LTG.

KW - Boron-doped diamond

KW - Chronoamperometry

KW - Cyclic voltammetry

KW - Lamotrigine

KW - Microelectrode

UR - http://www.scopus.com/inward/record.url?scp=85044784564&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044784564&partnerID=8YFLogxK

U2 - 10.1016/j.electacta.2018.03.112

DO - 10.1016/j.electacta.2018.03.112

M3 - Article

AN - SCOPUS:85044784564

VL - 271

SP - 35

EP - 40

JO - Electrochimica Acta

JF - Electrochimica Acta

SN - 0013-4686

ER -