Elevated level of plasma basic fibroblast growth factor in multiple myeloma correlates with increased disease activity

Norihide Sato, Yutaka Hattori, Du Wenlin, Taketo Yamada, Tamihiro Kamata, Tsunayuki Kakimoto, Shinichiro Okamoto, Chiharu Kawamura, Masahiro Kizaki, Naoki Shimada, Yukiko Ote, Jun Ichi Hata, Yasuo Ikeda

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Recent reports that bone marrow angiogenesis is increased in multiple myeloma prompted us to examine plasma concentrations of angiogenic growth factors and to elucidate their clinical and biological significance. In 45 cases including 36 cases of multiple myeloma and 9 cases of monoclonal gammopathies of undetermined significance (MGUS), plasma concentrations of basic fibroblast growth factor (FGF-2) and vascular endothelial growth factor (VEGF) were evaluated. FGF-2 was significantly elevated in 25 out of 45 (56%) of the patients with multiple myeloma compared with control subjects (median 9.01 pg/ml vs. 1.58 pg/ml, P<0.0001). The 25 cases were all active multiple myeloma, and none of the non-active myeloma and MGUS patients showed a high FGF-2 level. VEGF level was also elevated in 26 out of 45 patients (58%) compared with control subjects (median 42.0 pg/ml vs. 15.8 pg/ml, P<0.0001 for VEGF). VEGF concentration was high in 20 active myelomas, but also in one non-active myeloma and five MGUS. Elevation of FGF-2 level was associated with β2-microglobulin level, anemia and bone marrow plasma cell percentage, which represent disease activity. Interestingly, none of five Bence-Jones type myelomas, including four clinically active cases, revealed a high plasma FGF-2 level, while all of them showed a high VEGF level. In all five responders, the plasma FGF-2 levels were significantly decreased after chemotherapy. FGF-2 was immunohistochemically detected in the bone marrow myeloma cells of the patients with high plasma FGF-2 level. We conclude that plasma concentration of FGF-2 can be a useful indicator of disease activity.

Original languageEnglish
Pages (from-to)459-466
Number of pages8
JournalJapanese Journal of Cancer Research
Volume93
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • Angiogenesis
  • Basic fibroblast growth factor
  • Disease activity
  • Multiple myeloma
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Sato, N., Hattori, Y., Wenlin, D., Yamada, T., Kamata, T., Kakimoto, T., Okamoto, S., Kawamura, C., Kizaki, M., Shimada, N., Ote, Y., Hata, J. I., & Ikeda, Y. (2002). Elevated level of plasma basic fibroblast growth factor in multiple myeloma correlates with increased disease activity. Japanese Journal of Cancer Research, 93(4), 459-466. https://doi.org/10.1111/j.1349-7006.2002.tb01278.x