Elevated levels of interleukin-8 and leukotriene B4 in pulmonary edema fluid of a patient with reexpansion pulmonary edema

Hidetoshi Nakamura, Akitoshi Ishizaka, Makoto Sawafuji, Tetsuya Urano, Seitaro Fujishima, Fumio Sakamaki, Koichi Sayama, Masafumi Kawamura, Ryoichi Kato, Koji Kikuchi, Minoru Kanazawa, Koichi Kobayashi, Takeo Kawashiro

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


We experienced a case of reexpansion pulmonary edema (RPE) after surgical treatment of pneumothorax. In this case, protein leakage and polymorphonuclear leukocyte (PMN) accumulation were observed in the reexpanded lung. Interleukin-8 and leukotriene B4 in edema fluid were increased at the onset of RPE. PMN elastase was also increased, though its peak was delayed. The plasma level of P-selectin, which mediates adhesion between PMN and endothelium, was elevated. We speculate that some of these fluid mediators may play important roles in chemotaxis and activation of PMN in the development of RPE.

Original languageEnglish
Pages (from-to)1037-1040
Number of pages4
JournalAmerican journal of respiratory and critical care medicine
Issue number4
Publication statusPublished - 1994 Apr

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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