Elevated plasma RANTES in primary biliary cirrhosis patients

Shingo Miyaguchi, Oda Masaya, Hiroyuki Imaeda, Yoshikazu Tsuzuki, Masaya Mori, Hidetsugu Saito, Hiromasa Ishii

Research output: Contribution to journalArticle

Abstract

RANTES (regulated on activation, normal T cell expressed and secreted) is a member of a large supergene family of proinflammatory cytokines called C-C chemokines and it is expressed by T lymphocytes, fibroblasts, endothelial cells, platelets, mesangial cells, and renal tubular epithelial cells. RANTES is chemotactic for eosinophils, basophils, monocytes/macrophages, and CD4 + memory T cells. This chemokine plays an important role in allergic inflammation and autoimmune responses in a variety of diseases, such as asthma and rheumatoid arthritis. However, there have been few studies on RANTES in liver disease. In an attempt to assess the relationships between plasma RANTES levels and the stages of primary biliary cirrhosis (PBC), the present study was designed to measure plasma RANTES levels in plasma by the ELISA in patients with PBC and chronic hepatitis C (CHC) and liver cirrhosis (LC) and in healthy subjects. Plasma RANTES levels in patients with PBC were significantly higher than in those with LC and in healthy subjects. They were also significantly higher in stages I and II of PBC (group A) than in stages III and IV of PBC (group B). There was a significant correlation between peripheral eosinophil counts and plasma RANTES levels. A significant correlation was also noted between the grade of eosinophil infiltration and the plasma RANTES levels. It was concluded RANTES plays an important role in the early stages of PBC.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalHepatology Research
Volume8
Issue number3
Publication statusPublished - 1997 Sep

Fingerprint

Biliary Liver Cirrhosis
T-Lymphocytes
Eosinophils
Liver Cirrhosis
Healthy Volunteers
CC Chemokines
Mesangial Cells
Basophils
Chronic Hepatitis C
Autoimmunity
Chemokines
Liver Diseases
Monocytes
Rheumatoid Arthritis
Blood Platelets
Asthma
Endothelial Cells
Fibroblasts
Epithelial Cells
Enzyme-Linked Immunosorbent Assay

Keywords

  • Eosinophil
  • PBC
  • RANTES

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Miyaguchi, S., Masaya, O., Imaeda, H., Tsuzuki, Y., Mori, M., Saito, H., & Ishii, H. (1997). Elevated plasma RANTES in primary biliary cirrhosis patients. Hepatology Research, 8(3), 156-163.

Elevated plasma RANTES in primary biliary cirrhosis patients. / Miyaguchi, Shingo; Masaya, Oda; Imaeda, Hiroyuki; Tsuzuki, Yoshikazu; Mori, Masaya; Saito, Hidetsugu; Ishii, Hiromasa.

In: Hepatology Research, Vol. 8, No. 3, 09.1997, p. 156-163.

Research output: Contribution to journalArticle

Miyaguchi, S, Masaya, O, Imaeda, H, Tsuzuki, Y, Mori, M, Saito, H & Ishii, H 1997, 'Elevated plasma RANTES in primary biliary cirrhosis patients', Hepatology Research, vol. 8, no. 3, pp. 156-163.
Miyaguchi S, Masaya O, Imaeda H, Tsuzuki Y, Mori M, Saito H et al. Elevated plasma RANTES in primary biliary cirrhosis patients. Hepatology Research. 1997 Sep;8(3):156-163.
Miyaguchi, Shingo ; Masaya, Oda ; Imaeda, Hiroyuki ; Tsuzuki, Yoshikazu ; Mori, Masaya ; Saito, Hidetsugu ; Ishii, Hiromasa. / Elevated plasma RANTES in primary biliary cirrhosis patients. In: Hepatology Research. 1997 ; Vol. 8, No. 3. pp. 156-163.
@article{be01a4202bd1486ba413546bd0abba97,
title = "Elevated plasma RANTES in primary biliary cirrhosis patients",
abstract = "RANTES (regulated on activation, normal T cell expressed and secreted) is a member of a large supergene family of proinflammatory cytokines called C-C chemokines and it is expressed by T lymphocytes, fibroblasts, endothelial cells, platelets, mesangial cells, and renal tubular epithelial cells. RANTES is chemotactic for eosinophils, basophils, monocytes/macrophages, and CD4 + memory T cells. This chemokine plays an important role in allergic inflammation and autoimmune responses in a variety of diseases, such as asthma and rheumatoid arthritis. However, there have been few studies on RANTES in liver disease. In an attempt to assess the relationships between plasma RANTES levels and the stages of primary biliary cirrhosis (PBC), the present study was designed to measure plasma RANTES levels in plasma by the ELISA in patients with PBC and chronic hepatitis C (CHC) and liver cirrhosis (LC) and in healthy subjects. Plasma RANTES levels in patients with PBC were significantly higher than in those with LC and in healthy subjects. They were also significantly higher in stages I and II of PBC (group A) than in stages III and IV of PBC (group B). There was a significant correlation between peripheral eosinophil counts and plasma RANTES levels. A significant correlation was also noted between the grade of eosinophil infiltration and the plasma RANTES levels. It was concluded RANTES plays an important role in the early stages of PBC.",
keywords = "Eosinophil, PBC, RANTES",
author = "Shingo Miyaguchi and Oda Masaya and Hiroyuki Imaeda and Yoshikazu Tsuzuki and Masaya Mori and Hidetsugu Saito and Hiromasa Ishii",
year = "1997",
month = "9",
language = "English",
volume = "8",
pages = "156--163",
journal = "Hepatology Research",
issn = "1386-6346",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",

}

TY - JOUR

T1 - Elevated plasma RANTES in primary biliary cirrhosis patients

AU - Miyaguchi, Shingo

AU - Masaya, Oda

AU - Imaeda, Hiroyuki

AU - Tsuzuki, Yoshikazu

AU - Mori, Masaya

AU - Saito, Hidetsugu

AU - Ishii, Hiromasa

PY - 1997/9

Y1 - 1997/9

N2 - RANTES (regulated on activation, normal T cell expressed and secreted) is a member of a large supergene family of proinflammatory cytokines called C-C chemokines and it is expressed by T lymphocytes, fibroblasts, endothelial cells, platelets, mesangial cells, and renal tubular epithelial cells. RANTES is chemotactic for eosinophils, basophils, monocytes/macrophages, and CD4 + memory T cells. This chemokine plays an important role in allergic inflammation and autoimmune responses in a variety of diseases, such as asthma and rheumatoid arthritis. However, there have been few studies on RANTES in liver disease. In an attempt to assess the relationships between plasma RANTES levels and the stages of primary biliary cirrhosis (PBC), the present study was designed to measure plasma RANTES levels in plasma by the ELISA in patients with PBC and chronic hepatitis C (CHC) and liver cirrhosis (LC) and in healthy subjects. Plasma RANTES levels in patients with PBC were significantly higher than in those with LC and in healthy subjects. They were also significantly higher in stages I and II of PBC (group A) than in stages III and IV of PBC (group B). There was a significant correlation between peripheral eosinophil counts and plasma RANTES levels. A significant correlation was also noted between the grade of eosinophil infiltration and the plasma RANTES levels. It was concluded RANTES plays an important role in the early stages of PBC.

AB - RANTES (regulated on activation, normal T cell expressed and secreted) is a member of a large supergene family of proinflammatory cytokines called C-C chemokines and it is expressed by T lymphocytes, fibroblasts, endothelial cells, platelets, mesangial cells, and renal tubular epithelial cells. RANTES is chemotactic for eosinophils, basophils, monocytes/macrophages, and CD4 + memory T cells. This chemokine plays an important role in allergic inflammation and autoimmune responses in a variety of diseases, such as asthma and rheumatoid arthritis. However, there have been few studies on RANTES in liver disease. In an attempt to assess the relationships between plasma RANTES levels and the stages of primary biliary cirrhosis (PBC), the present study was designed to measure plasma RANTES levels in plasma by the ELISA in patients with PBC and chronic hepatitis C (CHC) and liver cirrhosis (LC) and in healthy subjects. Plasma RANTES levels in patients with PBC were significantly higher than in those with LC and in healthy subjects. They were also significantly higher in stages I and II of PBC (group A) than in stages III and IV of PBC (group B). There was a significant correlation between peripheral eosinophil counts and plasma RANTES levels. A significant correlation was also noted between the grade of eosinophil infiltration and the plasma RANTES levels. It was concluded RANTES plays an important role in the early stages of PBC.

KW - Eosinophil

KW - PBC

KW - RANTES

UR - http://www.scopus.com/inward/record.url?scp=0343052565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0343052565&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0343052565

VL - 8

SP - 156

EP - 163

JO - Hepatology Research

JF - Hepatology Research

SN - 1386-6346

IS - 3

ER -