Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities

Makoto Suzuki, Tomonori Nakamura, Sachi Iyoki, Akihiro Fujiwara, Yuhya Watanabe, Kunihiko Mohri, Kimiaki Isobe, Kageyoshi Ono, Shingo Yano

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73 Citations (Scopus)

Abstract

The anti-allergic and anti-oxidative activities of curcumin-related compounds (glycosides, reductants and bis-demethoxy analogs) were investigated to elucidate the underlying active mechanisms and structural features of curcumin in exerting these activities. The anti-allergic activities were assessed by measurement of histamine release from rat basophilic leukemia cells, RBL-2H3. Curcumin and tetrahydrocurcumin (THC) caused a marked decrease in histamine release. Glycosides of curcumin, bis-demethoxycurcumin and THC also inhibited the release of histamine, though less potently than curcumin did. The anti-oxidative activities were assessed by measurement of cell-free or cellular radical scavenging. All compounds but diglycosides or bis-demethoxycurcumin analogs distinctly exerted anti-oxidative effects. The relationship between both of these activities revealed that all compounds with potent radical scavenging activities caused a definite decrease in histamine release, but some compounds with non-potent radical scavenging activities also inhibited the histamine release. These results suggest that the hydroxy groups of curcumin play a significant role in exerting both the anti-oxidative and antiallergic activities, and that most of the compounds develop the anti-allergic activities through mechanisms related to anti-oxidative activities, but some through mechanisms unrelated to anti-oxidation activity.

Original languageEnglish
Pages (from-to)1438-1443
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume28
Issue number8
DOIs
Publication statusPublished - 2005 Aug 1
Externally publishedYes

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Keywords

  • Anti-allergic effect
  • Anti-oxidative effect
  • Curcumin
  • Curcumin-related compound
  • Tetrahydrocurcumin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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