Emergence in japan of an HIV-1 variant associated with transmission among men who have sex with men (MSM) in china: First indication of the international dissemination of the chinese MSM Lineage

Makiko Kondo, Philippe Lemey, Takako Sano, Ichiro Itoda, Yukihiro Yoshimura, Hiroko Sagara, Natsuo Tachikawa, Ko Yamanaka, Shinya Iwamuro, Tetsuro Matano, Mitsunobu Imai, Shingo Kato, Yutaka Takebe

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Abstract

A survey of HIV-1 strains circulating in the Tokyo-Kanagawa metropolitan area of Japan during 2004 to 2011 (n + 477) identified six Japanese males (patients 1 to 6), who harbored viruses with genome segments derived from a distinct CRF01_AE variant uniquely found among men who have sex with men (MSM) in China (designated CN.MSM.01-1). These six HIV infections were diagnosed in 2010 and 2011 among MSM (3 of 75) and men with unknown risk factors (3 of 63) and differed from the vast majority of HIV infections among MSM in Japan, which are overwhelmingly characterized by subtype B (239 of 246 [97.2%]). Approximately one-third (91 of 239 [38.1%]) of subtype B strains from MSM in Japan belong to a large monophyletic cluster (designated JP.MSM.B-1). In addition, we identified a smaller subtype B cluster (n + 8) (designated JP.MSM.B-2) that also contains strains from two Chinese MSM living in Japan. Interestingly, patients 5 and 6 were found to be coinfected with CRF01_AE (CN.MSM.01-1) and subtype B (JP.MSM.B-2 or JP.MSM.B-1) variants that are unique to the HIV-1 epidemics among MSM in China and Japan, respectively. Our study demonstrates for the first time the effect of the expanding HIV epidemic among MSM in China on transmission in neighboring countries and shows the ongoing mixing of CRF01_AE and subtype B lineages unique to HIV-1 that cocirculate in MSM populations in East Asia. This finding highlights the importance of strengthening epidemiological surveillance in the region and the need for effective measures to limit transmission among MSM in East Asia.

Original languageEnglish
Pages (from-to)5351-5361
Number of pages11
JournalJournal of Virology
Volume87
Issue number10
DOIs
Publication statusPublished - 2013 May

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ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Kondo, M., Lemey, P., Sano, T., Itoda, I., Yoshimura, Y., Sagara, H., Tachikawa, N., Yamanaka, K., Iwamuro, S., Matano, T., Imai, M., Kato, S., & Takebe, Y. (2013). Emergence in japan of an HIV-1 variant associated with transmission among men who have sex with men (MSM) in china: First indication of the international dissemination of the chinese MSM Lineage. Journal of Virology, 87(10), 5351-5361. https://doi.org/10.1128/JVI.02370-12