Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation

Yosuke Isobe, Taiga Kato, Makoto Arita

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Acute inflammation and its resolution are essential processes for tissue protection and homeostasis. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programs that enable inflamed tissues to return to homeostasis. The mechanisms by which acute inflammation is resolved are of interest, and research in recent years has uncovered new endogenous anti-inflammatory and proresolving lipid mediators (i.e., lipoxins, resolvins, protectin, and maresin) generated from polyunsaturated fatty acids (PUFAs).This review presents new insights into the cellular and molecular mechanisms of inflammatory resolution, especially the roles of eosinophils, and a series of omega-3 PUFA-derived anti-inflammatory lipid mediators that they generate.

Original languageEnglish
Article numberArticle 270
JournalFrontiers in Immunology
Volume3
Issue numberAUG
DOIs
Publication statusPublished - 2012

Keywords

  • Eosinophils
  • Lipid mediator
  • Lipidomics
  • Lipoxygenase
  • Resolution of inflammation
  • Resolvins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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