En route to an efficient catalytic asymmetric synthesis of AS-3201

Tomoyuki Mashiko, Keiichi Hara, Daisuke Tanaka, Yuji Fujiwara, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

109 Citations (Scopus)

Abstract

A catalytic asymmetric synthesis of AS-3201 via catalytic asymmetric amination with a novel lanthanum-amide complex is described. The amination reaction proceeded efficiently with as little as 1 mol % of catalyst loading, allowing for an efficient access to the key intermediate for the synthesis of AS-3201, a potent aldose reductase inhibitor.

Original languageEnglish
Pages (from-to)11342-11343
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number37
DOIs
Publication statusPublished - 2007 Sep 19
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint

Dive into the research topics of 'En route to an efficient catalytic asymmetric synthesis of AS-3201'. Together they form a unique fingerprint.

Cite this