Abstract
We report here the synthesis of enantio-pair-type fluorescence-labeled probes based on phyllanthurinolactone (1), which is a leaf-closing substance of Phyllanthus urinaria L. Moreover, the application of an enantio-differential approach to distinguish between specific and nonspecific binding of ligands and receptors was performed. Fluorescence studies using a natural-type probe 6 and a nonnatural-type probe 7 revealed that the target cell for 1 is a motor cell. Furthermore, our results lead to the suggestion that some receptors, which recognize the stereochemistry of the aglycon of 1, exist on the plasma membrane of the motor cell, as do leaf-opening substances.
Original language | English |
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Pages (from-to) | 7702-7705 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 48 |
Issue number | 43 |
DOIs | |
Publication status | Published - 2007 Oct 22 |
Externally published | Yes |
Keywords
- Enantio-differential
- Fluorescence-probe
- Leaf-closing substance
- Nyctinasty
- Phyllanthurinolactone
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry