Abstract
(Matrix Presented) 1,4-Addition (Michael addition) of 2-hydroxy-2′-methoxyacetophenone (2) to various αβ-unsaturated ketones was efficiently promoted by a bimetallic Zn-Zn-linked-BINOL complex 3 with good yield (up to 90%) and excellent enantiomeric excess (up to 99% ee). The resulting 2-hydroxy-1,5-diketones were successfully converted to synthetically more versatile esters and amides.
Original language | English |
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Pages (from-to) | 4251-4254 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 3 |
Issue number | 26 |
DOIs | |
Publication status | Published - 2001 Dec 27 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry