Enantioselective catalytic ring opening of epoxides with carboxylic acids

Eric N. Jacobsen, Fumitoshi Kakiuchi, Reed G. Konsler, Jay F. Larrow, Makoto Tokunaga

Research output: Contribution to journalArticle

256 Citations (Scopus)


The chiral Co(salen) complex 3 is an effective catalyst for the asymmetric ring-opening of meso epoxides with benzoic acid. Enantioselectivities of 55-93% were obtained with a range of substrates.

Original languageEnglish
Pages (from-to)773-776
Number of pages4
JournalTetrahedron Letters
Issue number5
Publication statusPublished - 1997 Feb 3


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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