Enantioselective Distribution of Amino-Alcohols in a Liquid-Liquid Two-Phase System Containing Dialkyl L-Tartrate and Boric Acid

Yoshihiro Abe, Tomoko Shoji, Michi Kobayashi, Wang Qing, Naoko Asai, Hideyuki Nishizawa

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Racemic amino-alcohols such as pindolol, propranolol, alprenolol and bucumolol enantiomers exhibited different distribution behaviors in a two-phase system consisting of a chloroform solution of didodecyl L-tartrate and an aqueous solution of boric acid. It seemed that a borate complex of the 1,2-diol group of the tartrate and the amino-alcohol was formed in the system. In the case of pindolol, one enantiomer was preferentially extracted into the organic phase (× 2.20) at equilibrium.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Issue number2
Publication statusPublished - 1995 Jan 1



  • amino-alcohol
  • boric acid
  • didodecy L-tartrate
  • enantioseparation
  • liquid-liquid extraction

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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