Enantioselective glyoxylate-ene reaction using a novel spiro bis(isoxazoline) ligand in copper catalysis

Kazuhiko Wakita, Gan B. Bajracharya, Midori A. Arai, Shinobu Takizawa, Takeyuki Suzuki, Hiroaki Sasai

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Novel chiral spiro bis(isoxazoline) ligands 3 and 4 are synthesized from an optically active olefin. The Cu(II)-spiro bis(isoxazoline) complex prepared in situ from Cu(OTf)2 and 3 promoted the glyoxylate-ene reaction in high yield and moderate enantioselectivity (up to 70%).

Original languageEnglish
Pages (from-to)372-376
Number of pages5
JournalTetrahedron Asymmetry
Volume18
Issue number3
DOIs
Publication statusPublished - 2007 Feb 28
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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