Enantioselective oxidation of mandelic acid using a phenylmalonate metabolizing pathway of a soil bacterium Alcaligenesbronchisepticus KU 1201

Kenji Miyamoto; Hiromichi Ohta

doi:10.1007/BF01021248

Enantioselective oxidation of mandelic acid using a phenylmalonate metabolizing pathway of a soil bacterium Alcaligenesbronchisepticus KU 1201

Kenji Miyamoto, Hiromichi Ohta

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The metabolic pathway of phenylmalonic acid by Alcaligenesbronchisepticus KU1201, which catalyzes the asymmetric decarboxylation of α-aryl-α-methylmalonic acids to α-arylpropionic acids, is demonstrated. Enantioselective oxidation of mandelic acid was investigated using the metabolizing pathway in this strain. Incubation of (±)-mandelic acid with A.bronchisepticus afforded optically pure (R)-one accompanied by benzoylformic acid and benzoic acid. This enzymatic oxidation is also applicable to various substituted mandelic acids.

Original language	English
Pages (from-to)	363-366
Number of pages	4
Journal	Biotechnology Letters
Volume	14
Issue number	5
DOIs	https://doi.org/10.1007/BF01021248
Publication status	Published - 1992 May 1

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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title = "Enantioselective oxidation of mandelic acid using a phenylmalonate metabolizing pathway of a soil bacterium Alcaligenesbronchisepticus KU 1201",

abstract = "The metabolic pathway of phenylmalonic acid by Alcaligenesbronchisepticus KU1201, which catalyzes the asymmetric decarboxylation of α-aryl-α-methylmalonic acids to α-arylpropionic acids, is demonstrated. Enantioselective oxidation of mandelic acid was investigated using the metabolizing pathway in this strain. Incubation of (±)-mandelic acid with A.bronchisepticus afforded optically pure (R)-one accompanied by benzoylformic acid and benzoic acid. This enzymatic oxidation is also applicable to various substituted mandelic acids.",

author = "Kenji Miyamoto and Hiromichi Ohta",

year = "1992",

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doi = "10.1007/BF01021248",

language = "English",

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journal = "Biotechnology Letters",

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T1 - Enantioselective oxidation of mandelic acid using a phenylmalonate metabolizing pathway of a soil bacterium Alcaligenesbronchisepticus KU 1201

AU - Miyamoto, Kenji

AU - Ohta, Hiromichi

PY - 1992/5/1

Y1 - 1992/5/1

N2 - The metabolic pathway of phenylmalonic acid by Alcaligenesbronchisepticus KU1201, which catalyzes the asymmetric decarboxylation of α-aryl-α-methylmalonic acids to α-arylpropionic acids, is demonstrated. Enantioselective oxidation of mandelic acid was investigated using the metabolizing pathway in this strain. Incubation of (±)-mandelic acid with A.bronchisepticus afforded optically pure (R)-one accompanied by benzoylformic acid and benzoic acid. This enzymatic oxidation is also applicable to various substituted mandelic acids.

AB - The metabolic pathway of phenylmalonic acid by Alcaligenesbronchisepticus KU1201, which catalyzes the asymmetric decarboxylation of α-aryl-α-methylmalonic acids to α-arylpropionic acids, is demonstrated. Enantioselective oxidation of mandelic acid was investigated using the metabolizing pathway in this strain. Incubation of (±)-mandelic acid with A.bronchisepticus afforded optically pure (R)-one accompanied by benzoylformic acid and benzoic acid. This enzymatic oxidation is also applicable to various substituted mandelic acids.

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JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 5

ER -

Enantioselective oxidation of mandelic acid using a phenylmalonate metabolizing pathway of a soil bacterium Alcaligenesbronchisepticus KU 1201

Abstract

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