Enantioselective Reduction of Ketones with Sodium Borohydride, Catalyzed by Optically Active (β‐Oxoaldiminato)cobalt(II) Complexes

Takushi Nagata; Kiyotaka Yorozu; Tohru Yamada; Teruaki Mukaiyama

doi:10.1002/anie.199521451

Enantioselective Reduction of Ketones with Sodium Borohydride, Catalyzed by Optically Active (β‐Oxoaldiminato)cobalt(II) Complexes

Takushi Nagata, Kiyotaka Yorozu, Tohru Yamada, Teruaki Mukaiyama

Research output: Contribution to journal › Article › peer-review

155 Citations (Scopus)

Abstract

Asymmetric reduction of prochiral ketones with sodium borohydride proceeds in the presence of catalytic amounts of optically active β‐oxoaldiminatocobalt(II) complexes 1 to the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities (68–94% ee). (Figure Presented.)

Original language	English
Pages (from-to)	2145-2147
Number of pages	3
Journal	Angewandte Chemie International Edition in English
Volume	34
Issue number	19
DOIs	https://doi.org/10.1002/anie.199521451
Publication status	Published - 1995 Oct 16
Externally published	Yes

Keywords

asymmetric syntheses
catalysis
chiral auxiliaries
cobalt compounds
reductions

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.199521451

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title = "Enantioselective Reduction of Ketones with Sodium Borohydride, Catalyzed by Optically Active (β‐Oxoaldiminato)cobalt(II) Complexes",

abstract = "Asymmetric reduction of prochiral ketones with sodium borohydride proceeds in the presence of catalytic amounts of optically active β‐oxoaldiminatocobalt(II) complexes 1 to the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities (68–94% ee). (Figure Presented.)",

keywords = "asymmetric syntheses, catalysis, chiral auxiliaries, cobalt compounds, reductions",

author = "Takushi Nagata and Kiyotaka Yorozu and Tohru Yamada and Teruaki Mukaiyama",

year = "1995",

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day = "16",

doi = "10.1002/anie.199521451",

language = "English",

volume = "34",

pages = "2145--2147",

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T1 - Enantioselective Reduction of Ketones with Sodium Borohydride, Catalyzed by Optically Active (β‐Oxoaldiminato)cobalt(II) Complexes

AU - Nagata, Takushi

AU - Yorozu, Kiyotaka

AU - Yamada, Tohru

AU - Mukaiyama, Teruaki

PY - 1995/10/16

Y1 - 1995/10/16

N2 - Asymmetric reduction of prochiral ketones with sodium borohydride proceeds in the presence of catalytic amounts of optically active β‐oxoaldiminatocobalt(II) complexes 1 to the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities (68–94% ee). (Figure Presented.)

AB - Asymmetric reduction of prochiral ketones with sodium borohydride proceeds in the presence of catalytic amounts of optically active β‐oxoaldiminatocobalt(II) complexes 1 to the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities (68–94% ee). (Figure Presented.)

KW - asymmetric syntheses

KW - catalysis

KW - chiral auxiliaries

KW - cobalt compounds

KW - reductions

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U2 - 10.1002/anie.199521451

DO - 10.1002/anie.199521451

M3 - Article

AN - SCOPUS:33748216114

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SP - 2145

EP - 2147

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 19

ER -

Enantioselective Reduction of Ketones with Sodium Borohydride, Catalyzed by Optically Active (β‐Oxoaldiminato)cobalt(II) Complexes

Abstract

Keywords

ASJC Scopus subject areas

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