Enantioselective Reduction of Ketones with Sodium Borohydride, Catalyzed by Optically Active (β‐Oxoaldiminato)cobalt(II) Complexes

Takushi Nagata, Kiyotaka Yorozu, Tohru Yamada, Teruaki Mukaiyama

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Asymmetric reduction of prochiral ketones with sodium borohydride proceeds in the presence of catalytic amounts of optically active β‐oxoaldiminatocobalt(II) complexes 1 to the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities (68–94% ee). (Figure Presented.)

Original languageEnglish
Pages (from-to)2145-2147
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume34
Issue number19
DOIs
Publication statusPublished - 1995 Oct 16
Externally publishedYes

Keywords

  • asymmetric syntheses
  • catalysis
  • chiral auxiliaries
  • cobalt compounds
  • reductions

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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