Enantioselective synthesis of α-methylene-γ-butyrolactones using chiral Pd(II)-SPRIX catalyst

Chinnasamy Muthiah, Midori A. Arai, Toshio Shinohara, Takayoshi Arai, Shinobu Takizawa, Hiroaki Sasai

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Combination of Pd(OCOCF3)2 and (M,S,S)-iPr-SPRIX ligand promoted the intramolecular cyclization of 2-alkynoates very effectively to form α-methylene-γ-butyrolactones in good yields with up to 92% ee.

Original languageEnglish
Pages (from-to)5201-5204
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number28
DOIs
Publication statusPublished - 2003 Jul 7
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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