Enantioselective transfer hydrogenation of difluoromethyl ketimines using benzothiazoline as a hydrogen donor in combination with a chiral phosphoric acid

Tsubasa Sakamoto, Kosaku Horiguchi, Kodai Saito, Keiji Mori, Takahiko Akiyama

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Hold the benzothiazoline: Highly enantioselective transfer hydrogenation of difluoromethyl ketimines with benzothiazolines catalyzed by a chiral phosphoric acid furnishes α-difluoromethylated amines in good yields and with excellent enantioselectivity, irrespective of the stereochemistry of the starting materials. PMP=p-methoxyphenyl.

Original languageEnglish
Pages (from-to)943-946
Number of pages4
JournalAsian Journal of Organic Chemistry
Volume2
Issue number11
DOIs
Publication statusPublished - 2013 Nov

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Keywords

  • Benzothiazolines
  • Chiral phosphoric acids
  • Difluoromethyl amines
  • Difluoromethyl ketimines
  • Enantioselective transfer hydrogenation

ASJC Scopus subject areas

  • Organic Chemistry

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