Abstract
Applicable also for other pseudosugars, the simple reaction sequence for the preparation of α‐D‐glucosidase inhibitors valiolamine (1) and its three diastereoisomers starts with 1,3,4,5‐tetrahydroxycyclohexanecarboxylic acid (quinic acid). Glycosidase inhibitors like 1 are used as chemotherapeutics, for example, against HIV. (Figure Presented.)
| Original language | English |
|---|---|
| Pages (from-to) | 1643-1645 |
| Number of pages | 3 |
| Journal | Angewandte Chemie International Edition in English |
| Volume | 34 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 1995 Aug 18 |
Keywords
- aminosugars
- asymmetric syntheses
- dihydroxylations
- quinic acid
- valiolamine
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Shing, T. K. M., & Wan, L. H. (1995). Enantiospecific Syntheses of Valiolamine and its (1R), (2R), (1R, 2R) Diastereomers from (−)‐Quinic Acid. Angewandte Chemie International Edition in English, 34(15), 1643-1645. https://doi.org/10.1002/anie.199516431