Enantiospecific synthesis of (+)-altholactone and its three stereoisomers

Tony K.M. Shing, John G. Gillhouley

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


(+)-Altholactone 1 and (+)-7-epi-altholactone 3 were constructed from D-gulonolactone whereas their respective enantiomers (-)-altholactone 2 and (-)-7-epi- altholactone 4 were synthesised from D-mannose, involving stereocontrolled reduction of the lactols 21 and 12 as a key step.

Original languageEnglish
Pages (from-to)8685-8698
Number of pages14
Issue number29
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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